Interactions Between MAOA and SYP Polymorphisms were Associated with Symptoms of Attention-Deficit/Hyperactivity Disorder in Chinese Han Subjects
Interactions Between MAOA and SYP Polymorphisms were Associated with Symptoms of Attention-Deficit/Hyperactivity Disorder in Chinese Han Subjects
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MAOA 和 SYP 多态性之间的相互作用与中国汉族受试者的注意力缺陷/多动障碍症状相关
DOI：
10.1002/ajmg.b.32273
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Qian, Qiu-Jin
中科院分区：
文献类型：
--
作者：
Gao, Qian;Liu, Lu;Qian, Qiu-Jin
单胺氧化酶A（monoamine oxidase A，MAOA）和突触素（synaptophysin，SYP）作为注意缺陷多动障碍（attention-deficit/hyperactivity disorder，ADHD）的候选基因，均位于X染色体上，被认为与注意力不集中型（dominantly inattentionable subtype，ADHD-I）相关。本研究旨在探讨中国汉族人群中MAOA基因rs 5905859和SYP基因rs 5906754与ADHD的潜在基因-基因交互作用（G × G）。在以家庭为基础的关联研究中，纳入了177名女性三人组。在病例对照研究中，收集了1，462名先证者和807名正常对照。采用ADHDRating Scale-IV（ADHD-RSIV）量表评定ADHD症状。基于家系的广义多因素降维（PGMDR）的女性ADHD三人组表明，rs 5905859和rs 5906754显着的基因互作效应。广义多因素降维（GMDR）表明，潜在的基因-基因相互作用的ADHD RS-IV分数在女性ADHD-I。在病例对照分析中，男性受试者中未观察到相关性。因此，MAOA和SYP的相互作用可能参与了ADHD-I亚型的遗传机制，并预测ADHD症状。(C)2014 Wiley Periodicals，Inc.
As candidate genes of attention-deficit/hyperactivity disorder (ADHD), monoamine oxidase A (MAOA), and synaptophysin (SYP) are both on theXchromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD-I). The present study is to investigate the potential gene-gene interaction (G x G) between rs5905859 of MAOA and rs5906754 of SYP for ADHD in Chinese Han subjects. For family-based association study, 177 female trios were included. For case-control study, 1,462 probands and 807 normal controls were recruited. TheADHDRating Scale-IV(ADHD-RSIV) was used to evaluate ADHD symptoms. Pedigree-based generalized multifactor dimensionality reduction (PGMDR) for female ADHD trios indicated significant gene interaction effect of rs5905859 and rs5906754. Generalized multifactor dimensionality reduction (GMDR) indicated potential gene-gene interplay on ADHD RS-IV scores in female ADHD-I. No associations were observed in male subjects in case-control analysis. In conclusion, our findings suggested that the interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype and predict ADHD symptoms. (C) 2014 Wiley Periodicals, Inc.