Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study.
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study.
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使用甘油晶体的角膜组织对深层的层状角膜成形术进行临床评估，用于难治性疱疹性基质角膜炎：一项观察性研究。
DOI：
10.1097/md.0000000000004892
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发表时间：
2016-09
期刊：
影响因子：
1.6
通讯作者：
Bi Y
中科院分区：
文献类型：
--
作者：
Liu X;Zhou Q;Huang X;Liu Z;Bi Y
本研究旨在评价使用甘油冷冻保存的角膜组织（GCCT）进行深前板层角膜移植术（DALK）治疗屈光性单纯疱疹性角膜炎（HSK）患者的疗效。这篇文章是一个回顾性、非比较性和干预性病例系列。2012年至2015年，HSK患者在上海同济医院使用GCCT进行DALK。观察最佳矫正视力、复发性炎症、移植物状态、术后中央移植物厚度和术前/术后并发症。随访时间为24.4 ± 5.6个月（范围：16-38个月）。 总的来说，最佳眼镜矫正视力从术前的HM/10 cm增加到0.15，术后12个月增加到0.41± 0.14（范围：0.1-0.8; P <0.05）。 术中发生微穿孔4眼（14.81%），排斥反应3眼（11.1%），全部逆转。2眼（7.41%）HSK复发，1眼HSK反复复发，最终导致永久性角膜混浊，患者拒绝再次移植。最终随访时，平均整个角膜厚度为0.519 ± 0.018 mm（范围：0.5-0.56 mm），平均移植物厚度为0.405 ± 0.033 mm（范围：0.35-0.47 mm）。 使用GCCT的DALK被证明是治疗难治性HSK的有效和安全的疗法。
The study aimed to evaluate the therapeutic effects of deep anterior lamellar keratoplasty (DALK) using glycerol-cryopreserved corneal tissues (GCCTs) in patients with refractive herpes simplex keratitis (HSK). This article was a retrospective, noncomparative, and interventional case series. Patients with HSK underwent DALK using GCCTs at Shanghai Tongji Hospital from 2012 to 2015. The best spectacle corrected visual acuity, recurrent inflammation, graft status, postoperative central graft thickness, and pre/postoperative complications were detected. The follow-up ranged from 24.4 ± 5.6 months (range: 16–38 months). Overall, the best spectacle corrected visual acuity was increased from HM/10 cm to 0.15 before surgery to 0.41 ± 0.14 (range: 0.1–0.8; P < 0.05) at 12 months postoperatively. Intraoperative microperforation occurred in 4 eyes (14.81%), and rejection episodes were encountered in 3 of 27 eyes (11.1%), and all of the eyes reversed. HSK recurred in 2 eyes (7.41%), 1 eye with repeated recurring HSK, and eventually led to perpetual corneal opacity and the patient refused a retransplantation. The mean entire corneal thickness was 0.519 ± 0.018 mm (range: 0.5–0.56 mm) and the mean graft thickness was 0.405 ± 0.033 mm (range: 0.35–0.47 mm) in the final follow-up. The DALK using GCCTs was proven to be an effective and safe therapy in treating refractory HSK.