Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland
Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland
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DOI：
10.1542/peds.110.3.627
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发表时间：
2002-09-01
期刊：
影响因子：
8
通讯作者：
Etzel, RA
中科院分区：
文献类型：
--
作者：
Dearborn, DG;Smith, PG;Etzel, RA
1993年至2000年间，克利夫兰彩虹婴儿和儿童医院有30名婴儿因急性肺出血住院。大多数婴儿表现出严重的肺部症状，需要强化支持，但少数婴儿出血较轻。四分之三的患者需要呼吸机支持和输血。11例有短暂性血红蛋白尿。5名患者死亡，但幸存下来的婴儿情况良好。目前还没有具体的治疗方法，尽管我们建议搬到另一个家，避免环境中的烟草烟雾。随后，下呼吸道再出血的婴儿从7例中的5例减少到21例中的1例。基于减少随后的致命性出血，高剂量糖皮质激素似乎是有一定价值的。几名患者在初次出血后持续轻度肺泡出血数月，甚至在离开原来的家庭环境后。
Between 1993 and 2000, 30 infants were hospitalized with acute pulmonary hemorrhage at Rainbow Babies and Children's Hospital in Cleveland. Most infants presented with severe pulmonary symptoms requiring intensive support, but a few infants had less severe hemorrhage. Three quarters of the patients required ventilator support and blood transfusions. Eleven patients had transitory hemoglobinuria. Five patients died, but infants who survived did well. There are currently no specific treatment modalities, although we have advised moving to a different home and avoiding environmental tobacco smoke. Subsequently, rebleeding from the lower respiratory tract has decreased from 5 of 7 infants to 1 in 21. On the basis of decreased subsequent fatal hemorrhage, high dose glucocorticoids seem to be of some value. Several patients revealed continued low-grade alveolar hemorrhage for months after their initial bleed, even after removal from their original home environments.