No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.
No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.
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DOI：
10.1158/1055-9965.epi-08-0789
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Calle EE
中科院分区：
文献类型：
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作者：
Stevens VL;Rodriguez C;Sun J;Talbot JT;Thun MJ;Calle EE
一碳代谢介导叶酸的相互转化，以合成用于DNA合成、修复和甲基化的前体。叶酸营养不足或代谢受损会破坏这些过程并促进致癌作用。在这项研究中，我们调查了9个一碳代谢基因中39个候选SNP与前列腺癌风险的关系，使用了来自癌症预防研究-II营养队列的1，144例病例和1，144例对照。无论是总体还是晚期前列腺癌病例，这些SNP均与前列腺癌风险无显着相关。因此，我们的研究结果不支持一碳代谢基因中常见的遗传变异影响前列腺癌风险的假设。
One-carbon metabolism mediates the inter-conversion of folates for the synthesis of precursors used in DNA synthesis, repair and methylation. Inadequate folate nutrition or compromised metabolism can disrupt these processes and facilitate carcinogenesis. In this study, we investigated associations of 39 candidate SNPs in nine one-carbon metabolism genes with risk of prostate cancer using 1,144 cases and 1,144 controls from the Cancer Prevention Study-II Nutrition Cohort. None of these SNPs were significantly associated with prostate cancer risk, either overall or in cases with advanced prostate cancer. Thus, our findings do not support the hypothesis that common genetic variation in one-carbon metabolism genes influences prostate cancer risk.