Statistical analysis of amino acids in the vicinity of carbohydrate residues performed by GlyVicinity.
Statistical analysis of amino acids in the vicinity of carbohydrate residues performed by GlyVicinity.
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GlyVicinity 对碳水化合物残基附近的氨基酸进行统计分析。
DOI：
10.1007/978-1-4939-2343-4_16
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发表时间：
2015
影响因子：
--
通讯作者：
Thomas Lütteke
中科院分区：
文献类型：
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作者：
Miguel A. Rojas;Thomas Lütteke
蛋白质-碳水化合物的相互作用涉及到各种基本的生物事件。来自蛋白质数据库(PDB)的三维结构数据可以帮助理解蛋白质识别碳水化合物的特异性的分子基础。这种相互作用可以使用GlyVicity进行统计分析。本章举例说明如何使用这一工具查找特定氨基酸在单个碳水化合物残基附近出现的频率信息，并分析相互作用原子的类型及其在多糖周围的空间分布。
Protein-carbohydrate interactions are involved in various essential biological events. 3D structural data from the Protein Data Bank (PDB) can help to understand the molecular basis of the specificity of carbohydrate recognition by proteins. Such interactions can be analyzed statistically using GlyVicinity. This chapter exemplifies the usage of this tool to find information on the frequency of the occurrence of specific amino acids in the vicinity of individual carbohydrate residues and to analyze the type of interacting atoms and their spatial distribution around the glycans.