A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility
A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility
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北京结核分枝杆菌的一个主要亚群与多重耐药性和传播性增加有关
DOI：
10.1017/s0950268810000890
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Xu, B.
中科院分区：
文献类型：
--
作者：
Hu, Y.;Ma, X.;Xu, B.
摘要本研究进一步调查了中国农村流行的北京家族结核分枝杆菌与抗结核（TB）耐药性的关系。通过基于人群的流行病学研究，共收集到351株结核分枝杆菌，其中223株（63.5%）对至少一种抗结核药物耐药，其中53株（15.1%）为多药耐药（MDR）菌株。spoligo分型发现243株（69.2%）属于北京家系。分枝杆菌穿插重复单元（MIRU）基因分型（223325173533）鉴定的北京家系主要亚群MDR（44.7%比13.7%,OR 6.18, 95% CI 2.68 ~ 14.23）、katG和rpoB突变（31.6%比9.3%,OR 4.27, 95% CI 1.86 ~ 9.80）和IS6110 RFLP基因分型聚类（65%比21.0%,OR 6.14, 95% CI 2.82 ~ 13.37）的频率显著高于其他北京家系分离株。我们的数据表明，北京家族的MIRU基因型223325173533与耐多药和增加的传播性有关。
SUMMARY This study investigated further the association between the Beijing family Mycobacterium tuberculosis circulating in rural China and anti-tuberculosis (TB) drug resistance. In total, 351 M. tuberculosis isolates were collected through a population-based epidemiological study, 223 (63·5%) of which were resistant to at least one anti-TB drug, including 53 (15·1%) multidrug-resistant (MDR) isolates. Spoligotyping found 243 isolates (69·2%) that belonged to the Beijing family. A major subgroup of the Beijing family identified by mycobacterial interspersed repetitive unit (MIRU) genotyping (223325173533), showed significantly higher frequencies of MDR (44·7% vs. 13·7%, OR 6·18, 95% CI 2·68–14·23), katG and rpoB mutations (31·6% vs. 9·3%, OR 4·27, 95% CI 1·86–9·80), and being clustered by IS6110 RFLP genotyping (60·5% vs. 21·0%, OR 6·14, 95% CI 2·82–13·37) in comparison with other Beijing family isolates. Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility.