Hypoxia-inducible factors in physiology and medicine.
Hypoxia-inducible factors in physiology and medicine.
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DOI:
10.1016/j.cell.2012.01.021
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发表时间:
2012-02-03
期刊:
影响因子:
64.5
通讯作者:
Semenza GL
中科院分区:
文献类型:
--
作者:
Semenza GL
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
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影响因子:
29.4
作者:
Cummins, Eoin P.;Seeballuck, Fergal;Taylor, Cormac T.
通讯作者:
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DOI:
10.1073/pnas.1002443107
发表时间:
2010-06-22
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64.5
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