Hypoxia-inducible factors in physiology and medicine.

Hypoxia-inducible factors in physiology and medicine.
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DOI:
10.1016/j.cell.2012.01.021
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发表时间:
2012-02-03
期刊:
影响因子:
64.5
通讯作者:
Semenza GL
Semenza GL
中科院分区:
生物学1区
文献类型:
--
作者:
Semenza GL

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氧稳态代表了理解后生动物进化、发育、生理学和病理学的组织原则。低氧诱导因子(HIF)是一种转录激活因子,在所有后生动物物种中起着氧稳态的主要调节剂的作用。在阐明HIF在许多生理系统中的稳态作用、确定慢性疾病中HIF失调的病理后果以及研究HIF用于治疗目的的潜在靶向方面正在取得快速进展。
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
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