Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.
Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.
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DOI：
10.1084/jem.179.2.757
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发表时间：
1994-02-01
期刊：
影响因子：
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通讯作者：
Banchereau J
中科院分区：
文献类型：
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作者：
Brière F;Servet-Delprat C;Bridon JM;Saint-Remy JM;Banchereau J
在抗原诱导的免疫应答期间，人B细胞将同种型从免疫球蛋白M（IgM）-IgD转换为IgG 1 -4、IgA 1 -2或IgE。在人体中，尚未证实细胞因子可作为IgG 1、IgG 2和IgG 3的转换因子。在本文中，我们报告，在响应白细胞介素10（IL-10），抗CD 40激活的扁桃体表面IgD+（sIgD+）B细胞被诱导分泌大量的IgM，IgG 1和IgG 3，但既不IgG 2也不IgG 4。脐血纯化B细胞和Hyper-IgM患者的淋巴细胞在与抗CD 40和IL-10培养后也产生IgG 1和IgG 3。相反，sIgD-同种型定型B细胞在IL-10存在下通过CD 40活化时产生IgG 1、IgG 2和IgG 3。因此，除了其对人B细胞的生长促进和分化活性外，IL-10可能代表IgG 1和IgG 3的转换因子。
During antigen-induced immune responses, human B cells switch isotype from immunoglobulin M (IgM)-IgD to IgG1-4, IgA1-2, or IgE. In the human, no cytokines have yet been demonstrated to act as switch factors for IgG1, IgG2, and IgG3. In this paper, we report that in response to interleukin 10 (IL-10), anti-CD40 activated tonsillar surface IgD+ (sIgD+) B cells are induced to secrete large amounts of IgM, IgG1, and IgG3 but neither IgG2 nor IgG4. Cord blood purified B cells and lymphocytes from Hyper-IgM patients also produced IgG1 and IgG3 after culture with anti-CD40 and IL-10. In contrast, sIgD- isotype-committed B cells produce IgG1, IgG2, and IgG3 when activated through CD40 in the presence of IL-10. Thus, in addition to its growth-promoting and differentiating activities on human B cells, IL-10 may represent a switch factor for IgG1 and IgG3.