Proatherogenic role of elevated CE transfer from HDL to VLDL1 and dense LDL in type 2 diabetes -: Impact of the degree of triglyceridemia
Proatherogenic role of elevated CE transfer from HDL to VLDL1 and dense LDL in type 2 diabetes -: Impact of the degree of triglyceridemia
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DOI：
10.1161/01.atv.21.2.282
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发表时间：
2001-02-01
影响因子：
8.7
通讯作者：
Chapman, MJ
中科院分区：
文献类型：
--
作者：
Guérin, M;Le Goff, W;Chapman, MJ
血浆胆固醇酯转移蛋白（CETP）通过促进中性脂质的异质交换促进血管内脂蛋白重塑。为了确定甘油三酯血症的程度是否会影响2型糖尿病患者cetp介导的高密度脂蛋白CE在致动脉粥样硬化血浆脂蛋白颗粒之间的再分配，我们评估了2型糖尿病患者血浆中CE从HDL到含载脂蛋白受体的质量传递（n=38）。同时，我们研究了CE转移与致动脉粥样硬化致密LDL分布之间的潜在关系。根据空腹血浆甘油三酯（TG）水平将糖尿病人群分为3个亚组：1组（G1）
Plasma cholesteryl ester transfer protein (CETP) facilitates intravascular lipoprotein remodeling by promoting the heteroexchange of neutral lipids. To determine whether the degree of triglyceridemia may influence the CETP-mediated redistribution of HDL CE between atherogenic plasma lipoprotein particles in type 2 diabetes, we evaluated CE mass transfer from HDL to apoB-containing lipoprotein accepters in the plasma of type 2 diabetes subjects (n=38). In parallel, we investigated the potential relationship between CE transfer and the appearance of an atherogenic dense LDL profile. The diabetic population was divided into 3 subgroups according to fasting plasma triglyceride (TG) levels: group 1 (G1), TG