Strategies to enhance patient recruitment and retention in research involving patients with a first episode of mental illness
Strategies to enhance patient recruitment and retention in research involving patients with a first episode of mental illness
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DOI：
10.1016/j.cct.2008.07.005
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发表时间：
2008-11-01
影响因子：
2.2
通讯作者：
Zipursky, Robert B.
中科院分区：
文献类型：
--
作者：
Furimsky, Ivana;Cheung, Amy H.;Zipursky, Robert B.
招募和保留研究参与者往往是临床试验中最劳动密集型和最困难的组成部分。较差的招募和保留往往是成功完成临床试验的主要障碍。事实上，由于招聘和保留率低，许多研究提前终止，或者他们的研究结果受到质疑。对首发精神疾病的青年进行临床试验，在招募和留住方面面临更多挑战，包括与参与和家庭参与有关的障碍。为了对首发精神疾病制定有效的早期干预措施，有必要制定战略，加强在这一患者群体中的招募和留住。本文介绍了在两个临床试验中经历的招募和保留挑战：一个是参与者经历了第一次抑郁症发作，另一次是参与者经历了第一次精神病发作。在患者层面和临床医生层面都确定和审查了招募和保留方面的挑战。还讨论了在这两项研究中为加强招聘和留住而实施的战略。最后，还强调了在实施这些战略时需要考虑的伦理问题。(C)2008 Elsevier Inc.保留所有权利。
Recruitment and retention of research participants is often the most labor-intensive and difficult component of clinical trials. Poor recruitment and retention frequently pose as a major barrier in the successful completion of clinical trials. in fact, many studies are prematurely terminated, or their findings questioned due to low recruitment and retention rates. The conduct of clinical trials involving youth with a first episode of mental illness comes with additional challenges in recruitment and retention including barriers associated with engagement and family involvement. To develop effective early interventions for first episode mental illness, it is necessary to develop strategies to enhance recruitment and retention in this patient population. This article presents the recruitment and retention challenges experienced in two clinical trials: one involving participants experiencing a first episode of depression and one involving participants experiencing a first episode psychosis. Challenges with recruitment and retention are identified and reviewed at both the patient level and clinician level. Strategies that were implemented to enhance recruitment and retention in these two studies are also discussed. Finally, ethical issues to consider when implementing these strategies are also highlighted. (C) 2008 Elsevier Inc. All rights reserved.