Gene expression associated with suicide attempts in US veterans
Gene expression associated with suicide attempts in US veterans
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DOI：
10.1038/tp.2017.179
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发表时间：
2017-09-05
影响因子：
6.8
通讯作者：
Yehuda, R.
中科院分区：
文献类型：
--
作者：
Flory, J. D.;Donohue, D.;Yehuda, R.
根据美国退伍军人事务部自杀预防办公室最近的一份报告，退伍军人占美国人口的8.5%，但占所有自杀死亡人数的18%。这项针对精神病患者(n=39；87%为男性)的研究的目的是将有一次或多次自杀未遂病史的退伍军人的血液基因表达数据与从未试图自杀的退伍军人进行比较。尝试者组和非尝试者组在年龄和种族/民族方面匹配，两组都包括有不同精神病史的退伍军人，包括创伤后应激障碍(PTSD)和物质使用障碍。退伍军人接受了终生精神病史的采访，包括对以前自杀未遂的详细评估，并提供了血样。独创性通路分析(IPA)的结果确定了几条与自杀企图相关的通路，包括哺乳动物的雷帕霉素靶标(MTOR)和WNT信号通路。这些途径特别令人感兴趣，因为它们在解释自杀行为的药物治疗方面所起的作用，包括使用氯胺酮和锂。这些结果表明，在平民中观察到的结果也与退伍军人有关，并为解释在尸检样本中观察到的结果提供了背景。总而言之，一项新出现的工作表明，血液和大脑样本的研究结果一致，这表明有可能识别自杀企图的分子预测因素。
According to a recent report from the Office of Suicide Prevention in the US Department of Veterans Affairs, veterans represent 8.5% of the US population, but account for 18% of all deaths from suicide. The aim of this study of psychiatric patients (n = 39; 87% male) was to compare blood gene expression data from veterans with a history of one or more suicide attempts to veterans who had never attempted suicide. The attempter and non-attempter groups were matched for age and race/ethnicity, and both groups included veterans with a diverse psychiatric history that included posttraumatic stress disorder (PTSD) and substance-use disorders. Veterans were interviewed for lifetime psychiatric history, including a detailed assessment of prior suicide attempts and provided a blood sample. Results of Ingenuity Pathway Analysis (IPA) identified several pathways associated with suicide attempts, including the mammalian target of rapamycin (mTOR) and WNT signaling pathways. These pathways are of particular interest, given their role in explaining pharmacological treatments for suicidal behavior, including the use of ketamine and lithium. These results suggest that findings observed in civilians are also relevant for veterans and provide a context for interpreting results observed in postmortem samples. In conclusion, an emerging body of work that shows consistency in findings across blood and brain samples suggests that it might be possible to identify molecular predictors of suicide attempts.