Long-term results of elective hepatectomy for the treatment of ruptured hepatocellular carcinoma
Long-term results of elective hepatectomy for the treatment of ruptured hepatocellular carcinoma
复制标题
DOI：
10.1007/s00534-007-1239-0
复制
发表时间：
2008-03-01
期刊：
影响因子：
--
通讯作者：
Tajiri, Takashi
中科院分区：
文献类型：
--
作者：
Yoshida, Hiroshi;Mamada, Yasuhiro;Tajiri, Takashi
背景/目的。根据日本肝癌研究组编制的《原发性肝癌临床病理研究通用规则》，即使肿瘤很小且孤立，破裂型肝细胞癌（HCC）也被归类为4期。我们研究了选择性肝切除术治疗肝细胞癌破裂的长期结果。193例HCC患者首次行肝切除术，无手术死亡。10例HCC破裂（破裂组），183例HCC未破裂（未破裂组）。肝细胞癌扩展在宏观上分为1期23例，2期71例，3期53例，4期46例。破裂组1年、5年和10年的累计生存率分别为90.0%、67.5%和20.3%。4期患者累积生存率未破裂组低于破裂组（P < 0.05）。破裂组患者与2期或3期患者的累积生存率无显著差异。肝癌破裂患者择期肝切除术后的生存率很好，即使该疾病被归类为4期。
Background/Purpose. According to the General rules for the clinical and pathological study of primary liver cancer, compiled by the Liver Cancer Study Group of Japan, ruptured hepatocellular carcinoma (HCC) is classified as stage 4, even if the tumor is small and solitary. We examined the long-term results of elective hepatectomy for the treatment of ruptured HCC.Methods. A first hepatectomy was performed without operative death in 193 patients with HCC. Ten patients had ruptured HCC ( ruptured group) and 183 patients had nonruptured HCC ( nonruptured group). The extension of HCC was macroscopically classified as stage 1 in 23 patients, stage 2 in 71, stage 3 in 53, and stage 4 in 46.Results. Cumulative survival rates in the ruptured group at 1, 5, and 10 years were 90.0%, 67.5%, and 20.3%, respectively. The cumulative survival rate was lower in patients with stage 4 disease in the nonruptured group than that in patients in the ruptured group ( P < 0.05). Cumulative survival rates did not differ significantly between patients in the ruptured group and those with stage 2 or stage 3 disease.Conclusions. Survival rates after elective hepatectomy in patients with ruptured HCC are good, even if the disease is classified as stage 4.