The effect of age on the association between body-mass index and mortality
The effect of age on the association between body-mass index and mortality
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DOI：
10.1056/nejm199801013380101
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发表时间：
1998-01-01
影响因子：
158.5
通讯作者：
Wood, JL
中科院分区：
文献类型：
--
作者：
Stevens, J;Cai, JW;Wood, JL
背景年龄对最佳体重的影响是有争议的，很少有研究有足够数量的受试者分析死亡率作为一个功能的身体质量指数跨年龄组。方法我们研究了死亡率超过12年的白色男性和女性谁参加了美国癌症协会的癌症预防研究I（从1960年至1972年）。这项分析中包括的62，116名男性和262，019名女性从未吸烟，在1959-1960年基线时没有心脏病，中风或癌症（皮肤癌除外）的病史，并且最近没有无意的体重减轻史。根据死亡证明确定死亡受试者的死亡日期和原因。在分析中，我们调整了年龄，教育水平，体力活动和酒精consumption.Results更大的体重指数（定义为体重公斤除以平方米的高度）和死亡率之间的关联进行了检查，在六个年龄组中，更高的体重指数与所有原因和心血管疾病的男性和女性高达75岁的死亡率。然而，与更大的体重指数相关的相对风险随着年龄的增长而下降。例如，对于心血管疾病的死亡率，30-44岁男性体重指数增加1的相对风险为1.10（95%置信区间，1.04 - 1.16），65-74岁男性为1.03（95%置信区间，1.02 - 1.05）。对于女性，相应的相对危险度估计值分别为1.08（95%置信区间，1.05至1.11）和1.02（95%置信区间，1.02至1.03）。结论超重增加了30至74岁成年人死于任何原因和心血管疾病的风险。在年轻受试者中，与体重较大相关的相对风险较高。(C)1998年，马萨诸塞州医学会。
Background The effect of age on optimal body weight is controversial, and few studies have had adequate numbers of subjects to analyze mortality as a function of body-mass index across age groups.Methods We studied mortality over 12 years among white men and women who participated in the American Cancer Society's Cancer Prevention Study I (from 1960 through 1972). The 62,116 men and 262,019 women included in this analysis had never smoked cigarettes, had no history of heart disease, stroke, or cancer (other than skin cancer) at base line in 1959-1960, and had no history of recent unintentional weight loss. The date and cause of death for subjects who died were determined from death certificates. The associations between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and mortality were examined for six age groups in analyses in which we adjusted for age, educational level, physical activity, and alcohol consumption.Results Greater body-mass index was associated with higher mortality from all causes and from cardiovascular disease in men and women up to 75 years of age. However, the relative risk associated with greater body-mass index declined with age. For example, for mortality from cardiovascular disease, the relative risk associated with an increment of 1 in the body-mass index was 1.10 (95 percent confidence interval, 1.04 to 1.16) for 30-to-44-year-old men and 1.03 (95 percent confidence interval, 1.02 to 1.05) for 65-to-74-year-old men. For women, the corresponding relative risk estimates were 1.08 (95 percent confidence interval, 1.05 to 1.11) and 1.02 (95 percent confidence interval, 1.02 to 1.03).Conclusions Excess body weight increases the risk of death from any cause and from cardiovascular disease in adults between 30 and 74 years of age. The relative risk associated with greater body weight is higher among younger subjects. (C) 1998, Massachusetts Medical Society.