Soft patchy nanoparticles from solution-phase self-assembly of binary diblock copolymers
Soft patchy nanoparticles from solution-phase self-assembly of binary diblock copolymers
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DOI：
10.1021/nl073027q
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发表时间：
2008-02-01
期刊：
影响因子：
10.8
通讯作者：
Pitera, Jed W.
中科院分区：
文献类型：
--
作者：
Srinivas, Goundla;Pitera, Jed W.
制造高度有序、无缺陷的纳米结构是纳米技术的一个关键挑战。自下而上的制造方法需要精确定义尺寸和形状的纳米构件。在这项工作中，我们提出了一种简单的方法来获得一种类型的构建块——软斑状纳米粒子——由一系列粗粒分子动力学模拟建议。具有共同疏水性嵌段但亲水性嵌段足够不同的两种不同二嵌段共聚物的二元混合物能够在水中可靠地自组装成“片状”球形胶束，并且两个亲水性嵌段在胶束核心表面上发生相分离。随后核的交联以固化斑驳的球体几何形状，应该允许进一步的分层组装。改变每种聚合物的亲水性与疏水性组成会产生从“片状球体”到“片状圆柱体”的形态变化。此外，通过控制块与溶剂的相互作用强度，可以选择性地将贴片放置在胶束的外表面上或内部。发现斑块的数量和尺寸很大程度上受二元共聚物混合物的组成控制。
The fabrication of highly ordered, defect-free nanostructures is a key challenge in nanotechnology. Bottom-up fabrication approaches require nanobuilding blocks of precisely defined size and shape. In this work we propose a simple approach to obtain one type of building block-soft patchy nanoparticles-suggested by a series of coarse grain molecular dynamics simulations. A binary mixture of two different diblock copolymers with a common hydrophobic block but sufficiently dissimilar hydrophilic blocks reliably self-assembles into a "patchy" spherical micelle in water, with phase separation of the two hydrophilic blocks on the surface of the micelle core. Subsequent crosslinking of the core to solidify the patchy sphere geometry should allow further hierarchical assembly. Altering the hydrophilic versus hydrophobic composition of each polymer yields a change of morphology from "patchy spheres" to "patchy cylinders". Furthermore, by controlling the interaction strength of the blocks with solvent, the patches can be selectively placed either on the outer surface or inside the core of the micelle. The number and size of the patches are found to be largely controlled by the composition of the binary copolymer mixture.