Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases
Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases
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DOI：
10.1111/j.1525-1438.2007.00799.x
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发表时间：
2007-01-01
影响因子：
4.8
通讯作者：
Kammerer, U.
中科院分区：
文献类型：
--
作者：
Krockenberger, M.;Honig, A.;Kammerer, U.
卵巢癌的肿瘤生物学尚不清楚。然而，众所周知，卵巢肿瘤，特别是癌，显示葡萄糖膜转运蛋白的表达升高，促进葡萄糖摄取。可以假设，增加的葡萄糖摄取导致更高的葡萄糖代谢。完全恶性转化癌的能量来源主要由有氧糖酵解提供，已知有几种途径。描述了转酮醇酶在有氧糖酵解中的关键作用。最近，一种新的转酮酶样酶称为转酮酶样1（TKTL 1）已被描述，连接有氧糖酵解的脂肪酸合成通过生产乙酰辅酶A。为了研究TKTL1在卵巢癌进展中的作用，我们检测了正常卵巢组织、卵巢交界性肿瘤和粘液性或浆液性乳头状卵巢腺癌的石蜡切片中TKTL1的表达。我们发现TKTL1在浆液性乳头状卵巢腺癌中的表达显著升高，这与研究组的不良预后参数相关。因此，可以假设TKTL1在卵巢癌代谢中起关键作用，并且其表达预测不良预后。TKTL1是否在卵巢癌肿瘤生物学中起重要作用，以及TKTL1作为特异性抗肿瘤治疗新靶点的潜在作用有待进一步研究。
Tumorbiology of ovarian cancer remains unclear. However, it is known that ovarian tumors, especially carcinomas, show elevated expression of glucose membrane transporters for facilitated glucose uptake. It can be assumed that increased glucose uptake leads to higher glucose metabolism. The energy resources of fully malignant transformed carcinomas are mainly supplied by aerobic glycolysis, for which several pathways are known. A key role in aerobic glycolysis is described for the transketolase enzymes. Recently, a novel transketolase-like enzyme called transketolase-like 1 (TKTL1) has been described that links aerobic glycolysis to the synthesis of fatty acids via production of acetyl-CoA. In order to investigate the role of TKTL1 for the progression of ovarian carcinomas, we examined paraffin sections of normal ovarian tissues, ovarian borderline tumors, and mucinous or serous papillary ovarian adenocarcinomas with respect to their expression of TKTL1. We identified a significantly elevated expression of TKTL1 in serous papillary ovarian adenocarcinomas, which correlates with poor prognostic parameters in the examined study group. Therefore, it can be assumed that TKTL1 plays a crucial role in ovarian cancer metabolism and that its expression predicts poor prognosis. Further investigations should be performed in order to evaluate whether this new enzyme is important for ovarian cancer tumorbiology and to analyze the potential role of TKTL1 as new target for specific antitumoral therapy.