Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma
Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma
复制标题
DOI：
10.18632/aging.202411
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Qian Xu
中科院分区：
文献类型：
--
作者：
Jiawei Zhou;Yugang Guo;Zheng Huo;Yuxin Xing;Jintao Fang;Guohui Ma;Qinghui Han;Mengzhen Wang;Qian Xu
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA-binding proteins that are reported to play a.crucial role in the pathogenic process of multiple malignancies. However, their expression patterns, clinical.application significance and prognostic values in invasive breast carcinoma (BRCA) remain unknown. In this.study, we investigated hnRNP family members in BRCA using accumulated data from Oncomine 4.5, UALCAN.Web portal and other available databases. We explored the expression and prognostic value level of hnRNPs in.BRCA. We further analyzed their association with the clinicopathological features of BRCA patients..Subsequently, we calculated the alteration frequency of hnRNPs, constructed the interaction network of.hnRNPs, and examined the potential coexpression genes of hnRNPs, revealing that HNRNPU and SYNCRIP are.the core molecular genes requiring further investigation for BRCA. We validated the immunohistochemistry.(IHC) pattern to simulate clinical applications based on pathology. Cell function experiments conducted in vitro.indicated that HNRNPU can promote epithelial-mesenchymal transition, functionally stimulating the invasion.capacity and inhibiting the viability of invasive BRCA cells. In summary, our systematic analysis demonstrated.that HNRNPU was the key molecule that played a fundamental role in BRCA metastasis, which may facilitate.the development of new diagnostic and prognostic markers for the analysis of BRCA progression.
