A self-reported instrument for prodromal symptoms of psychosis: Testing the clinical validity of the PRIME Screen-Revised (PS-R) in a Japanese population
A self-reported instrument for prodromal symptoms of psychosis: Testing the clinical validity of the PRIME Screen-Revised (PS-R) in a Japanese population
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DOI：
10.1016/j.schres.2008.08.018
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发表时间：
2008-12-01
影响因子：
4.5
通讯作者：
Mizuno, Masafumi
中科院分区：
文献类型：
--
作者：
Kobayashi, Hiroyuki;Nemoto, Takahiro;Mizuno, Masafumi
目的：精神病的早期干预需要一种简便、有用的评估工具，以便在早期识别具有前驱症状的个体。本研究的目的是通过比较非临床人群和临床人群的结果，来检验前驱症状筛查修订版（PS - R）这一包含12个项目的精神病前驱症状自评工具的临床效度。
方法：对1024名受试者（496名学生和528名门诊患者）使用PS - R进行评估。在528名患者中，随机招募115名患者，并使用前驱综合征结构化访谈（SIPS）进行测试，以确定PS - R的一致性效度。通过确定6个月随访期间向精神病的转化率来衡量PS - R的预测效度。
结果：以SIPS作为金标准，PS - R的特异度和敏感度分别为0.74和1.00。PS - R相对于SIPS的一致性效度为0.43。PS - R和SIPS的预测效度（定义为向精神病的转化率）分别为0.11和0.25。PS - R结果为阴性的患者无一例发展为精神病。
结论：我们的研究结果表明，PS - R具有较高的效度，在全科医疗和临床环境中使用都是可行的。这种自评工具是一种有用的筛查工具，可提醒临床医生注意具有精神病前驱症状的个体。（C）2008爱思唯尔有限公司。保留所有权利。
Objective: Early intervention for psychosis requires an easy, useful assessment instrument to identify subjects with prodromal symptoms at an early stage. The aim of this study was to test the clinical validity of the PRIME: Screen-Revised (PS-R), a 12-item self-reported instrument for prodromal symptoms of psychosis, by comparing the results for a non-clinical population with those for a clinical population.Method: The PS-R was administered to 1024 subjects (496 students and 528 outpatients). Of the 528 patients. 115 were randomly recruited and tested using the Structured Interview for Prodromal Syndromes (SIPS) to determine the concordant validity of the PS-R. The predictive validity of the PS-R was measured by determining the transition rate to psychosis during a 6-month follow-up period.Results: The specificity and sensitivity of the PS-R, using the SIPS as a gold standard, were 0.74 and 1.00. The concordant validity of the PS-R against the SIPS was 0.43. The predictive validity of the PS-R and the SIPS, defined as the transition rate to psychosis, were 0.11 and 0.25, respectively. None of the patients with negative PS-R results developed psychosis.Conclusions: Our findings showed that the PS-R was highly valid and that its usage is feasible in both general practice and clinical settings. This self-reported instrument represents a useful screening tool for alerting clinicians to subjects with psychotic prodromal symptoms. (C) 2008 Elsevier B.V. All rights reserved.