Synthesis of pyrrolidines via palladium(II)-catalyzed aerobic oxidative carboamination of butyl vinyl ether and styrenes with allyl tosylamides
Synthesis of pyrrolidines via palladium(II)-catalyzed aerobic oxidative carboamination of butyl vinyl ether and styrenes with allyl tosylamides
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DOI：
10.1021/ol061057e
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发表时间：
2006-07-20
期刊：
影响因子：
5.2
通讯作者：
Stahl, Shannon S.
中科院分区：
文献类型：
--
作者：
Scarborough, Christopher C.;Stahl, Shannon S.
钯催化烯丙基甲苯磺酰胺与丁基乙烯基醚和各种苯乙烯衍生物在室温下氧化偶联生成2，4-取代吡咯烷产物。分子氧与铜（II）助催化剂一起介导钯催化剂的再氧化。与苯乙烯底物的反应可以在开口烧瓶中进行，环境空气作为O-2源。几种非传统的助催化剂，包括邻苯二酚，环辛二烯，丙烯酸甲酯，对反应有有益的影响。
Palladium(II) catalyzes the oxidative coupling of allyl tosylamides with butyl vinyl ether and various styrene derivatives to produce 2,4-substituted pyrrolidine products at room temperature. Molecular oxygen together with a copper(II) cocatalyst mediates reoxidation of the palladium catalyst. The reactions with styrene substrates can be performed in an open flask with ambient air as the source of O-2. Several nontraditional cocatalysts, including catechol, cyclooctadiene, and methyl acrylate, have a beneficial effect on the reactions.