Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS)
Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS)
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DOI：
10.1016/j.schres.2008.11.014
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发表时间：
2009-03-01
影响因子：
4.5
通讯作者：
Ohmori, Tetsuro
中科院分区：
文献类型：
--
作者：
Tayoshi, Shin'Ya;Sumitani, Satsuki;Ohmori, Tetsuro
神经系统的改变被认为在精神分裂症的病理生理学中起重要作用。本研究旨在利用质子磁共振波谱（H-1-MRS）研究慢性精神分裂症患者前扣带皮层（ACC）和左侧基底节（ItBG）谷氨酸（Glu）等代谢产物的变化。此外，由于这种疾病的性别差异是已知的，我们研究了性别对这些代谢产物的影响。H-1-MRS进行了30例精神分裂症患者和25名健康人作为对照组的ACC和ItBG。结果显示，精神分裂症患者ACC中Glu、Gln、肌酸+磷酸肌酸（Cre）、肌醇（ml）、N-乙酰天冬氨酸（NAA）和胆碱化合物（Cho）的含量均显著低于对照组。性别对ACC中Gln含量和ItBG中Cre、NAA含量有显著影响; ACC中Gln水平男性高于女性，而男性受试者ItBG中Cre和NAA水平低于女性受试者。这些结果证实了神经元能系统的变化，并提示ml参与了精神分裂症(C)2008 Elsevier B. V.保留所有权利。
A change in the glutamatergic system is thought to play an important role in the pathophysiology of schizophrenia. The aim of this study was to investigate the changes in metabolites, including glutamate (Glu), in the anterior cingulate cortex (ACC) and the left basal ganglia (ItBG) of patients with chronic schizophrenia using proton magnetic resonance spectroscopy (H-1-MRS). In addition, since gender differences in this illness were known, we examined the effects of gender on these metabolites.The H-1-MRS was performed on the ACC and ItBG of 30 patients with schizophrenia and 25 healthy individuals who acted as the control group. The levels of Glu, glutamine (Gln), creatine plus phosphocreatine (Cre), myo-inositol (ml), N-acetylaspartate (NAA), and choline-containing compounds (Cho) were measured.Two-way analysis of variance revealed that the illness significantly affected the levels of Glu and ml in the ACC; both metabolites were lower in the patients with schizophrenia as compared to the control subjects. The results also revealed that gender significantly affected the level of Gln in the ACC and the levels of Cre and NAA in the ItBG; the level of Gln in the ACC were higher in male subjects versus female subjects, whereas Cre and NAA levels in the ItBG were lower in male subjects as compared to female subjects.These results confirmed a change in the glutamatergic system and suggested an involvement of ml in the pathophysiology of schizophrenia. (C) 2008 Elsevier B.V. All rights reserved.