Lubrication regimes in mesothelial sliding
Lubrication regimes in mesothelial sliding
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DOI：
10.1016/j.jbiomech.2004.10.012
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发表时间：
2005-12-01
影响因子：
2.4
通讯作者：
Butler, JP
中科院分区：
文献类型：
--
作者：
Loring, SH;Brown, RE;Butler, JP
为了正常运作，肺、心脏和其他器官必须经历形状和大小的变化，与周围的体壁滑动。目前尚不清楚覆盖这些器官和体壁的精细间皮表面在滑动过程中是否接触，或者润滑液中的流体动力学压力是否增加了它们表面之间的分离。为了解决这个问题，我们测量了9只大鼠腹壁在光滑玻璃表面上的盐水中滑动的间皮表面的摩擦系数（mu）。在生理滑动速度0.0123- 6.14cm/s，法向应力50- 2001 Pa时，随速度变化有显著性差异（P < 0.001）。平均而言，它在低速时相对较高（0.041 cm/s时为0.078），在中速时降至最小值（1.23 cm/s时为0.034），在较高速度时再次略微增加（6.14 cm/s时为0.045），与混合润滑状态一致，其中至少存在部分表面的流体动力学分离。我们的结论是，mesothelium表面，在生理条件下滑动，保护过度剪切的水动力压力，增加分离的表面。(c)2004爱思唯尔有限公司保留所有权利。
To function normally, the lungs, heart, and other organs must undergo changes in shape and size, sliding against surrounding body walls. It is not known whether the delicate mesothelial surfaces covering these organs and body wall are in contact during sliding, or if hydrodynamic pressure in the lubricating liquid increases separation between their surfaces. To address this question, we measured the coefficient of friction (mu) of the mesothelial surface of nine rat-abdominal walls sliding in saline on a smooth glass surface. Sliding at physiological velocities of 0.0123-6.14 cm/s with normal stresses of 50-2001Pa, It varied with velocity (P < 0.001). On average, It was relatively high at low speeds (0.078 at 0.041 cm/s), decreased to a minimum at intermediate speeds (0.034 at 1.23 cm/s), and increased slightly again at higher speeds (0.045 at 6.14 cm/s), consistent with a mixed lubrication regime in which there is at least partial hydrodynamic separation of surfaces. We conclude that mesothelial surfaces, sliding under physiological conditions, are protected from excessive shear by hydrodynamic pressures that increase separation of surfaces. (c) 2004 Elsevier Ltd. All rights reserved.