The role of flexible polymer interconnects in chronic tissue response induced by intracortical microelectrodes--a modeling and an in vivo study.
The role of flexible polymer interconnects in chronic tissue response induced by intracortical microelectrodes--a modeling and an in vivo study.
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柔性聚合物互连在皮质内微电极诱导的慢性组织反应中的作用——建模和体内研究。
DOI：
10.1109/iembs.2006.260517
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Kipke,DarylR
中科院分区：
文献类型：
--
作者：
Subbaroyan,Jeyakumar;Kipke,DarylR
由束缚引起的慢性组织反应是皮质内微电极植入失败的主要原因之一。在这项研究中，我们探索了这样一个假设：柔性互连件可以消除“微运动”力的应变，从而可以维持植入物周围的健康组织。有限元建模结果表明，柔性互连件，即聚酰亚胺 (E=2 GPa) 和聚二甲基硅氧烷 (PDMS，E=6 MPa)，分别将界面应变降低了 66% 和两个数量级。定量免疫组织化学结果表明，距植入物界面 60 微米处发生了显着的神经元损失。这与神经胶质原纤维酸性蛋白（GFAP）表达和模拟应变密切相关，作为距植入物距离的函数
Chronic tissue response induced by tethering is one of the major causes for implant failure in intracortical microelectrodes. In this study, we had explored the hypothesis that flexible interconnects could provide strain relief against forces of "micromotion" and hence could result in maintaining a healthy tissue surrounding the implant. Finite element modeling results indicated that flexible interconnects, namely polyimide (E=2 GPa) and polydimethylsiloxane (PDMS, E=6 MPa), reduced the interfacial strain by 66% and two orders of magnitude, respectively. Quantitative immunohistochemistry results indicated that significant neuronal loss occurred up to 60 mum from the implant interface. This was strongly correlated to both glial fibrillary acidic protein (GFAP) expression and simulated strain as a function of distance away from the implant