Cyclization of Bisphosphines to Phosphacycles via the Cleavage of Two Carbon-Phosphorus Bonds by Nickel Catalysis
Cyclization of Bisphosphines to Phosphacycles via the Cleavage of Two Carbon-Phosphorus Bonds by Nickel Catalysis
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DOI：
10.1021/acs.orglett.9b01355
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发表时间：
2019-06-07
期刊：
影响因子：
5.2
通讯作者：
Tobisu, Mamoru
中科院分区：
文献类型：
--
作者：
Fujimoto, Hayato;Kusano, Momoka;Tobisu, Mamoru
本文报道了镍催化的双膦衍生物环化反应。反应通过双膦的两个碳-磷键的断裂进行。与先前报道的钯催化剂不同，使用镍作为催化剂允许需要C（烷基）-P键断裂的环化。成功地分离了磷镍磷中间体，并通过X射线晶体学进行了表征。
The nickel-catalyzed cyclization of bisphosphine derivatives to form various phosphacycles is reported. The reaction proceeds via the cleavage of two carbon-phosphorus bonds of the bisphosphine. Unlike the previously reported palladium catalysts, the use of nickel as a catalyst allows for the cyclization that requires C(alkyl)-P bond cleavage. A phospha-nickelacycle intermediate was successfully isolated and characterized by X-ray crystallography.