Short-term memory of danger signals and environmental stimuli in immune cells
Short-term memory of danger signals and environmental stimuli in immune cells
复制标题
DOI：
10.1038/ni.2636
复制
发表时间：
2013-08-01
影响因子：
30.5
通讯作者：
Natoli, Gioacchino
中科院分区：
文献类型：
--
作者：
Monticelli, Silvia;Natoli, Gioacchino
免疫记忆的标准定义都是建立在这样一种理念上的：一旦被感染，动物就能更有效地抵御第二次感染。这种普遍的观点忽略了细胞暴露于病原体、危险信号和一般环境因子的不可避免的后果：刺激以短暂但持续的方式改变细胞特性和活性，这种方式延伸到暴露时间之外，并调节先天性和适应性免疫系统的细胞对二次刺激的反应。我们认为，这种短暂的现象代表了“短期记忆”的环境暴露和讨论的证据表明，这是介导的持久性的长寿命的调节分子，特别是一个子集的新沉积的染色质修饰和诱导的非编码RNA。
Standard definitions of immunological memory are all built on the idea that once infected, animals are protected more efficiently against a second infection. This common view overlooks an unavoidable consequence of the exposure of cells to pathogens, danger signals and environmental agents in general: stimuli change cell properties and activity in a transient yet sustained manner that extends beyond the exposure time and modulates the response of cells of both the innate and adaptive immune systems to secondary stimulation. We suggest that this transient phenomenon represents 'short-term memory' of environmental exposure and discuss the evidence that this is mediated by the persistence of long-lived regulatory molecules, notably a subset of newly deposited chromatin modifications and inducible noncoding RNAs.