Therapeutic angiogenesis for critical limb ischemia: invited commentary
Therapeutic angiogenesis for critical limb ischemia: invited commentary
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DOI：
10.1016/s0168-3659(01)00501-6
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发表时间：
2002-01-17
影响因子：
10.8
通讯作者：
Sarkar, R
中科院分区：
文献类型：
--
作者：
Messina, LM;Brevetti, LS;Sarkar, R
下肢动脉闭塞性疾病导致腿部组织缺血，在老年人中较为常见。在临床上，它可能无症状，在运动时引起肌肉疼痛，或进展到严重的缺血程度，可能导致肢体丧失。虽然搭桥手术和血管成形术增加了这些患者的肢体保留率，但对许多患者来说，截肢仍然是一个常见的结果。治疗性血管生成是指给药血管生成因子或编码这些因子的基因，以促进新生血管，从而增加缺血腿部的血流量。我们建立了后肢缺血动物模型，用于研究治疗性血管生成。我们选择一氧化氮作为我们实验的血管生成因子，因为它具有诱导血管生成、血管舒张和抑制炎症的能力。在这篇综述中，我们将讨论我们的后肢缺血模型的经验，以及讨论我们使用一氧化氮治疗血管生成的基因治疗的结果。(C) 2002年Elsevier Science B.V.出版
Lower extremity arterial occlusive disease results in tissue ischemia of the legs and is relatively common in the elderly. Clinically, it may be asymptomatic, cause muscle pain during exercise, or progress to a severe degree of ischemia that may result in limb loss. Although bypass surgery, and angioplasty have increased the rate of limb salvage in these patients, amputation of the affected limb remains a common outcome for many patients. Therapeutic angiogenesis is the administration of angiogenic factors, or genes encoding these factors, to promote neovascularization and thereby increase blood flow to the ischemic leg. We have developed an animal model of hindlimb ischemia in which to study therapeutic angiogenesis. We chose nitric oxide as the angiogenic factor for our experiments because of its ability to induce angiogenesis, vasodilation, and inhibit inflammation. In this review, we will discuss our experience with our model of hindlimb ischemia, as well as discuss our results of gene therapy for therapeutic angiogenesis using nitric oxide. (C) 2002 Published by Elsevier Science B.V.