Reevaluation of the two-component hypothesis for turning behaviour by manipulating activities in the striatum and the nucleus accumbens of intact rats.
Reevaluation of the two-component hypothesis for turning behaviour by manipulating activities in the striatum and the nucleus accumbens of intact rats.
复制标题
通过操纵完整大鼠纹状体和伏核的活动来重新评估转向行为的二元假说。
DOI：
10.1016/0014-2999(93)90264-i
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发表时间：
1993
影响因子：
5
通讯作者：
M. Kobayashi
中科院分区：
文献类型：
--
作者：
T. Saigusa;N. Koshikawa;M. Kitamura;M. Kobayashi
本文研究了多巴胺D1和D2受体兴奋在大鼠转向行为产生中的作用。在预先单侧注射非选择性多巴胺D1 D2受体拮抗剂顺式（Z）-氟哌噻吨的大鼠中（10 μ g 0.5 μ l），进入腹侧纹状体，喹吡罗选择性多巴胺D2受体激动剂SKF 38393（1、3、5、10 mg/kg ip）可诱导剂量依赖性的翻转行为，而SKF 38393（10 mg/kg ip）可诱导剂量依赖性的翻转行为。而选择性多巴胺D1受体激动剂（1、3、5、10 mg/kg ip）则无此作用。这两种药物一起的效果比单独使用喹吡罗的效果大得多，并且通过在同侧或对侧丘脑核中额外阻断多巴胺D1 D2受体而降低。通过将SKF 38393和quinpirole单侧注射到丘脑核中，确定丘脑核在转动行为中的作用。结果表明，将两种药物的混合物（SKF 38393 5 μg+ quinpirole 10 μg/0.5 μl）单侧注射到丘脑核中，产生转动，而注射单一药物则没有。阻断同侧腹侧纹状体的多巴胺D1-D2受体可使翻转消失，但对侧腹侧纹状体无此作用.阻断对侧丘脑腹侧核也可减少翻转。此外，将药物混合物注射到背侧或腹侧纹状体中不会产生转向。
The role of dopamine D 1 and D 2 receptor stimulation in the production of turning behaviour in rats was studied. In rats pretreated with unilateral injections of the non-selective dopamine D 1 D 2 receptor antagonist, cis (Z)-flupentixol (10 μ g 0.5 μ l), into the ventral striatum, quinpirole (1, 3, 5, 10 mg/kg ip), a selective dopamine D 2 receptor agonist, induced dose-dependent turning behaviour, while SKF 38393 (1, 3, 5, 10 mg/kg ip), a selective dopamine D 1 receptor agonist, did not. The effect of the two drugs together was much greater than the effect of quinpirole alone and was reduced by additional blockade of dopamine D 1 D 2 receptors in either the ipsilateral or contralateral nucleus accumbens. The role of the nucleus accumbens in turning behaviour was determined from the effects of unilateral injections of SKF 38393 and quinpirole into the nucleus accumbens in turning results show that unilateral injections of a mixture of the two drugs (SKF 38393 5 μg+ quinpirole 10 μg/0.5 μl) into the nucleus accumbens produced turning while injections of single drugs did not. Turning was abolished by the blockade of dopamine D 1 D 2 receptors in the ipsilateral but not contralateral ventral striatum. Turning was also reduced by the blockade of the contralateral nucleus accumbens. Moreover, turning was not produced by injections of the drug mixture into the dorsal or ventral striatum.