VALIDATION OF CLINICAL DIAGNOSTIC-CRITERIA FOR ALZHEIMERS-DISEASE
VALIDATION OF CLINICAL DIAGNOSTIC-CRITERIA FOR ALZHEIMERS-DISEASE
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DOI：
10.1002/ana.410240105
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发表时间：
1988-07-01
影响因子：
11.2
通讯作者：
BERG, L
中科院分区：
文献类型：
--
作者：
MORRIS, JC;MCKEEL, DW;BERG, L
阿尔茨海默病（AD）的临床研究一直受到诊断不准确的限制。我们采用明确的临床纳入和排除标准，以确定受试者与老年性痴呆的阿尔茨海默型（SDAT）。在一个连续的系列26尸检，从这个样本，AD组织学证实在所有科目，是主要的痴呆症。26名SDAT受试者中有17名被诊断为轻度痴呆。两个对照组进行了神经病理学检查，AD是不存在的。我们的结论是，研究SDAT的临床诊断标准，即使在其轻度阶段，是有效的。
Clinical investigaztions of Alzheimer''s disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects ith senile dementia of the Alzheimer type (SDAT). In a consecutive series of 26 postmortem examinations from this sample, AD was histologically verified in all subjects and was the primary dementing illness. Seventeen of the 26 SDAT subjects had been diagnosed when only mildly demented. Two control subjects were examined neuropathologically; AD was absent in both. We conclude that research clinical diagnostic criteria for SDAT, even in its mild stage, are valid.