INFLUENCES OF DIETARY-SODIUM ON FUNCTIONAL TASTE RECEPTOR DEVELOPMENT - A SENSITIVE PERIOD
INFLUENCES OF DIETARY-SODIUM ON FUNCTIONAL TASTE RECEPTOR DEVELOPMENT - A SENSITIVE PERIOD
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DOI：
10.1126/science.3175625
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发表时间：
1988-09-30
期刊：
影响因子：
56.9
通讯作者：
PRZEKOP, PR
中科院分区：
文献类型：
--
作者：
HILL, DL;PRZEKOP, PR
在胚胎第 8 天或之前限制母体膳食钠会降低后代鼓索神经对氯化钠的味觉反应。响应衰减显着；剥夺大鼠后代对氯化钠的反应约为对照动物的 40%。在胚胎第 10 天或之后开始低钠饮食并没有产生功能变化。因此，味觉系统存在一个敏感期，并且在产前两天内发生从最大环境敏感性到不敏感性的突然转变。此外，决定味膜成分发育命运的重要事件发生在味蕾最初形成之前。
Restriction of maternal dietary sodium on or before embryonic day 8 reduced taste responses of the chorda tympani nerve to sodium chloride in the offspring. The response attenuation was substantial; responses to sodium chloride in the offspring of deprived rats were approximately 40 percent of those in control animals. Instituting the low sodium diet at embryonic day 10 or later did not produce functional changes. Thus, a sensitive period for the gustatory system exists, and the abrupt transition from maximal environmental susceptibility to no susceptibility occurs during a 2-day prenatal period. Moreover, events important in determining the developmental fate of taste membrane components occur before the initial formation of taste buds.