A NOVEL COMPOUND, DEPUDECIN, INDUCES PRODUCTION OF TRANSFORMATION TO THE FLAT PHENOTYPE OF NIH3T3 CELLS TRANSFORMED BY RAS-ONCOGENE
A NOVEL COMPOUND, DEPUDECIN, INDUCES PRODUCTION OF TRANSFORMATION TO THE FLAT PHENOTYPE OF NIH3T3 CELLS TRANSFORMED BY RAS-ONCOGENE
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DOI：
10.1016/s0006-291x(05)80156-1
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发表时间：
1992-01-15
影响因子：
3.1
通讯作者：
MATSUTANI, S
中科院分区：
文献类型：
--
作者：
SUGITA, K;YOSHIDA, H;MATSUTANI, S
一种新化合物Depudecin在低浓度(1g mg/ml)时诱导Ki-ras转化的NIH3T3细胞产生扁平表型，这种作用是可逆的。经柔红霉素处理后，细胞内可见肌动蛋白应激纤维。在加入Depudecin后6h，细胞几乎完全恢复到扁平表型。Depudecin浓度为10μg/ml时，ras-mR NA的合成不足以逆转转化形态。
A novel compound, depudecin, induced production of the flat phenotype of Ki-ras-transformed NIH3T3 cells at the low concentration of 1gmg/ml. This effect was reversible. Actin stress fiber was detected in these cells after depudecin treatment. Almost complete reversion to the flat phenotype was observed at 6 h after depudecin addition. The synthesis ofras-mRNA did not decrease enough with depudecin treatment at the concentration of 10μg/ml to reverse the transformed morphology.