Lack of association between LGMN and Alzheimer’s disease in the Southern Han Chinese population
Lack of association between LGMN and Alzheimer’s disease in the Southern Han Chinese population
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DOI：
10.1111/ejn.14857
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发表时间：
2020-06
影响因子：
3.4
通讯作者：
Xinyue Zhang;Bin Jiao;Ling Weng;Yafang Zhou;Lina Guo;Xin Wang;Lu Zhou;Xi-xi Liu;Xue-wen Xiao;Hui Liu;Xiangyu Zhu;Chenping Li;Yuan Zhu;Qijie Yang;Zhuojie Lin;Ya-ling Jiang;Yafei Wen;Hui Zhou;Lu Shen;X. Liao
中科院分区：
文献类型：
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作者：
Xinyue Zhang;Bin Jiao;Ling Weng;Yafang Zhou;Lina Guo;Xin Wang;Lu Zhou;Xi-xi Liu;Xue-wen Xiao;Hui Liu;Xiangyu Zhu;Chenping Li;Yuan Zhu;Qijie Yang;Zhuojie Lin;Ya-ling Jiang;Yafei Wen;Hui Zhou;Lu Shen;X. Liao
最近，功能研究表明，legumain （LGMN）可切割淀粉样β蛋白前体和tau蛋白，促进老年斑和神经原纤维缠结的形成，这可能在阿尔茨海默病（AD）的发病机制中发挥重要作用。然而，LGMN在AD中的遗传作用尚未清楚阐明。在这里，我们使用Sanger测序来研究LGMN基因变异的单独立（单变异关联试验）和累积（基于基因的关联试验）效应作为AD的潜在易感因素，研究对象包括676例AD病例和365例来自华南汉族人群的老年对照。在单变量关联分析中，LGMN的常见变异均无统计学意义。在基于基因的分析中，LGMN基因也显示与AD没有关联。我们在阿尔茨海默病神经影像学倡议队列中的重复研究结果也显示LGMN和AD之间没有关联。这些发现表明LGMN基因可能不是AD发展的关键因素。
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β‐protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). However, the genetic role of LGMN in AD has not been clearly elucidated. Here, we used Sanger sequencing to investigate the single independent (single‐variant association test) and cumulative (gene‐based association test) effects of variants in the LGMN gene as potential susceptibility factors for AD, in a cohort comprising 676 AD cases and 365 elderly controls from the Han population of South China. In single‐variant association analysis, none of the common variants in LGMN were statistically significant. In gene‐based analysis, the LGMN gene also showed no association with AD. The results of our replication study in the Alzheimer's Disease Neuroimaging Initiative cohort also showed no association between LGMN and AD. These findings suggest that the LGMN gene may not be a critical factor for AD development.