Past, present, and possible future human infection with influenza virus A subtype H7.

Past, present, and possible future human infection with influenza virus A subtype H7.
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过去、现在和未来可能的人类感染甲型流感病毒 H7 亚型。

DOI:
10.3201/eid1506.090072
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发表时间:
2009-06
影响因子:
11.8
通讯作者:
Tumpey, Terrence M.
Tumpey, Terrence M.
中科院分区:
医学2区
文献类型:
--
作者:
Belser, Jessica A.;Bridges, Carolyn B.;Katz, Jacqueline M.;Tumpey, Terrence M.

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自 2002 年以来,这些病毒已导致超过 100 例人类感染病例,其大流行的潜力不容低估。自 2002 年以来,荷兰、意大利、加拿大、美国和英国甲型 H7 流感病毒已导致超过 100 例人类感染病例。 H7 亚型感染引起的临床疾病范围从结膜炎到轻度上呼吸道疾病再到肺炎。尽管 H7 亚型感染导致人类住院和死亡的比例低于 H5N1 亚型,但根据其病毒结合特性和暴露者的发病率,一些 H7 亚型毒株似乎更适合人类感染。此外,从家禽中分离出 H7 亚型流感病毒的增加以及该亚型引起严重人类疾病的能力强调了对这些病毒进行持续监测和表征的必要性。我们回顾一下H7亚型引起的人类感染史。此外,我们还讨论了最近发现的 H7 亚型病毒发病机制的分子相关性,并评估了当前预防未来 H7 亚型病毒感染的措施。
These viruses have resulted in >100 cases of human infection since 2002, and their pandemic potential should not be underestimated. Influenza A subtype H7 viruses have resulted in >100 cases of human infection since 2002 in the Netherlands, Italy, Canada, the United States, and the United Kingdom. Clinical illness from subtype H7 infection ranges from conjunctivitis to mild upper respiratory illness to pneumonia. Although subtype H7 infections have resulted in a smaller proportion of hospitalizations and deaths in humans than those caused by subtype H5N1, some subtype H7 strains appear more adapted for human infection on the basis of their virus-binding properties and illness rates among exposed persons. Moreover, increased isolation of subtype H7 influenza viruses from poultry and the ability of this subtype to cause severe human disease underscore the need for continued surveillance and characterization of these viruses. We review the history of human infection caused by subtype H7. In addition, we discuss recently identified molecular correlates of subtype H7 virus pathogenesis and assess current measures to prevent future subtype H7 virus infection.
DOI: 10.1128/jvi.01235-07
发表时间: 2007-10-01
影响因子: 5.4
作者:
Belser, Jessica A.;Lu, Xuihua;Tumpey, Terrence M.
通讯作者: Tumpey, Terrence M.
DOI: 10.3201/eid1012.040743
发表时间: 2004-12
影响因子: 11.8
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影响因子: 3.8
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影响因子: --
作者:
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