Development of the malaria parasite in the skin of the mammalian host
Development of the malaria parasite in the skin of the mammalian host
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DOI：
10.1073/pnas.1009346107
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发表时间：
2010-10-26
影响因子：
11.1
通讯作者：
Amino, Rogerio
中科院分区：
文献类型：
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作者：
Gueirard, Pascale;Tavares, Joana;Amino, Rogerio
脊椎动物体内疟原虫发育的第一步是由孢子子（蚊子在皮肤中注入的寄生虫阶段）转化为分裂子（侵入红细胞并引发疾病的阶段）。目前的观点是，在哺乳动物中，这个阶段的转化只发生在肝细胞内。在这里，我们记录了啮齿动物感染疟原虫的孢子子转化为小鼠皮肤中的分裂子。蚊子叮咬后，大约50%的寄生虫留在皮肤上，24小时后，大约10%的寄生虫在表皮和真皮层以及具有免疫功能的毛囊中发育，它们可以在那里存活数周。寄生虫在皮肤细胞中的发育途径，虽然经常流产，但会导致产生可感染红细胞的分裂子，并通过分裂体释放，如在肝脏中典型观察到的那样。因此，在啮齿动物感染疟疾期间，皮肤不仅是进入肝脏的途径，也是许多接种寄生虫的最终目的地，在那里它们可以分化成分裂子并可能持续存在。
The first step of Plasmodium development in vertebrates is the transformation of the sporozoite, the parasite stage injected by the mosquito in the skin, into merozoites, the stage that invades erythrocytes and initiates the disease. The current view is that, in mammals, this stage conversion occurs only inside hepatocytes. Here, we document the transformation of sporozoites of rodent-infecting Plasmodium into merozoites in the skin of mice. After mosquito bite, similar to 50% of the parasites remain in the skin, and at 24 h similar to 10% are developing in the epidermis and the dermis, as well as in the immunoprivileged hair follicles where they can survive for weeks. The parasite developmental pathway in skin cells, although frequently abortive, leads to the generation of merozoites that are infective to erythrocytes and are released via merosomes, as typically observed in the liver. Therefore, during malaria in rodents, the skin is not just the route to the liver but is also the final destination for many inoculated parasites, where they can differentiate into merozoites and possibly persist.