Supportive effect of interferential current stimulation on susceptibility of swallowing in guinea pigs
Supportive effect of interferential current stimulation on susceptibility of swallowing in guinea pigs
复制标题
干扰电流刺激对豚鼠吞咽敏感性的支持作用
DOI：
10.1007/s00221-018-5325-0
复制
发表时间：
2018
影响因子：
2
通讯作者：
Hirano Shigeru
中科院分区：
文献类型：
--
作者：
Umezaki Toshiro;Sugiyama Yoichiro;Fuse Shinya;Mukudai Shigeyuki;Hirano Shigeru
咽部吞咽的感觉-运动控制需要通过将食团引入咽部而诱发的来自咽部和喉部的感觉传入输入。咽和喉敏感性降低的患者可能有吞咽障碍，如吞咽触发延迟导致的吞咽前误吸。施加到颈部的干扰电流刺激被认为可以改善吞咽困难患者的吞咽功能，尽管这种刺激的易化作用的机制仍然未知。本研究观察了去大脑和麻痹豚鼠的孤束核和刺激邻近区吞咽诱发能力的变化以及吞咽相关神经元的反应。孤束核内注射红藻氨酸后，吞咽延迟时间明显缩短，而诱发吞咽的易化作用减弱。大约一半的吞咽相关神经元对刺激做出反应。这些数据表明，施加到颈部的干扰电流刺激可以增强咽和喉的感觉传入通路，使兴奋性输入到吞咽模式发生器的神经元，从而促进吞咽反射。
Sensory-motor control of the pharyngeal swallow requires sensory afferent inputs from the pharynx and larynx evoked by introducing bolus into the pharynx. Patients with reduced sensitivity of the pharynx and larynx are likely to have a swallowing impairment, such as pre-swallow aspiration due to delayed swallow triggering. Interferential current stimulation applied to the neck is thought to improve the swallowing function of dysphagic patients, although the mechanism underlying the facilitatory effect of such stimulation remains unknown. In the present study, we examined the changes in the elicitability of swallowing due to the stimulation and the responses of the swallowing-related neurons in the nucleus tractus solitarius and in the area adjacent to the stimulation in decerebrate and paralyzed guinea pigs. The swallowing delay time was shortened by the stimulation, whereas the facilitatory effect of eliciting swallowing was attenuated by kainic acid injection into the nucleus tractus solitarius. Approximately half of the swallowing-related neurons responded to the stimulation. These data suggest that the interferential current stimulation applied to the neck could enhance the sensory afferent pathway of the pharynx and larynx, subserving excitatory inputs to the neurons of the swallowing pattern generator, thereby facilitating the swallowing reflex.