Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma: Northeastern United States
Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma: Northeastern United States
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DOI：
10.1067/mob.2003.132
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发表时间：
2003-03-01
影响因子：
9.8
通讯作者：
Hildesheim, A
中科院分区：
文献类型：
--
作者：
Altekruse, SF;Lacey, JV;Hildesheim, A
目的：虽然人乳头瘤病毒基本上引起所有的宫颈癌，但辅因子可能因癌组织学类型而异。我们研究了人乳头瘤病毒基因型和性和生殖的危险因素宫颈腺癌和鳞状细胞cancer.Study设计：124名妇女腺癌，139名妇女鳞状细胞癌，和307名对照组参加了本病例对照研究。Logistic回归分析，计算比值比和Cls.Results：人乳头瘤病毒18型与腺癌（比值比，105; 95%CI，23-487）最强。人乳头瘤病毒16型与鳞状细胞癌的相关性最强（优势比，30; 95%CI，12-77）。终生性伴侣超过3个是腺癌（比值比，2.1; 95%CI，1.1-4.0）和鳞状细胞癌（比值比，3.0; 95%CI，1.6-5.9）的危险因素。甚至怀孕与腺癌呈负相关（比值比，0.4; 95%CI，0.2-0.8）。5次或5次以上妊娠与鳞状细胞癌相关（比值比，2.2; 95%CI，0.9-5.4）。结论：人乳头瘤病毒基因型16和18的相对重要性和生殖辅助因子的差异表明宫颈腺癌和鳞状细胞癌的不同原因。
OBJECTIVE: Although human papillomavirus causes essentially all cervical carcinoma, cofactors may differ by cancer histologic type. We examined human papillomavirus genotypes and sexual and reproductive risk factors for cervical adenocarcinoma and squamous cell carcinoma.STUDY DESIGN: One hundred twenty-four women with adenocarcinoma, 139 women with squamous cell carcinoma, and 307 control subjects participated in this case-control study. Logistic regression analyses were performed to calculate odds ratios and Cls.RESULTS: Human papillomavirus 18 was associated most strongly with adenocarcinoma (odds ratio, 105; 95% Cl, 23-487). Human papillomavirus 16 was associated most strongly with squamous cell carcinoma (odds ratio, 30; 95% Cl, 12-77). More than three lifetime sexual partners was a risk factor for adenocarcinoma (odds ratio, 2.1; 95% Cl, 1.1-4.0) and squamous cell carcinoma (odds ratio, 3.0; 95% Cl, 1.6-5.9). Even being pregnant was associated inversely with adenocarcinoma (odds ratio, 0.4; 95% Cl, 0.2-0.8). Five or more pregnancies was associated with squamous cell carcinoma (odds ratio, 2.2; 95% Cl, 0.9-5.4).CONCLUSION: The relative importance of human papillomavirus genotypes 16 and 18 and the reproductive co-factor differences suggest distinct causes for cervical adenocarcinoma and squamous cell carcinoma.