Comprehensive prognostic scoring systems could improve the prognosis of adult acute myeloid leukemia patients
Comprehensive prognostic scoring systems could improve the prognosis of adult acute myeloid leukemia patients
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综合预后评分系统可以改善成人急性髓系白血病患者的预后
DOI：
10.1007/s12185-019-02721-y
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发表时间：
2019-08
影响因子：
2.1
通讯作者：
Mei Heng
中科院分区：
文献类型：
--
作者：
Zhou Fan;Zhou Fen;Du Mengyi;Liu Lin;Guo Tao;Xia Linghui;Jin Runming;Hu Yu;Mei Heng
Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by a dismal outcome. To enable better outcomes, it is necessary to develop individual therapies based on risk stratification. In the present study, we established two new comprehensive prognostic scoring systems (CPSS) for overall survival (OS) and relapse-free survival (RFS) using the Cox proportional hazards regression, CPSS integrated and weighted age, AML type, lactic dehydrogenase (LDH), ECOG score, cytogenetics, and gene mutations. We divided patients into three risk groups—low-, intermediate-, and high-risk—with 1-year OS rates of 100.0%, 82.9%, and 38.2%, respectively (p< 0.0001), and patients undergoing complete remission (CR) were also separated into low-risk, intermediate-risk, and high-risk groups, with 1-year RFS rates of 87.7%, 58.4%, and 30.2%, respectively (p< 0.0001). We conclude that CPSS that integrate clinical characteristics, cytogenetic abnormalities, and gene mutations may improve the stratification of AML patients.
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影响因子：
3
作者：
C. Teng;Ji‐Hsiung Young;S. Hsu;G. Chou;Ing-Tiau Kuo;C. Yu;G. Hwang
通讯作者：
C. Teng;Ji‐Hsiung Young;S. Hsu;G. Chou;Ing-Tiau Kuo;C. Yu;G. Hwang
DOI：
10.1007/978-3-030-73227-1_13
发表时间：
2021
期刊：
Practical Oncologic Molecular Pathology
影响因子：
--
作者：
Guang Yang;Linsheng Zhang
通讯作者：
Guang Yang;Linsheng Zhang
影响因子：
4
作者：
Lin PH;Li HY;Fan SC;Yuan TH;Chen M;Hsu YH;Yang YH;Li LY;Yeh SP;Bai LY;Liao YM;Lin CY;Hsieh CY;Lin CC;Lin CH;Lien MY;Chen TT;Ni YH;Chiu CF
通讯作者：
Chiu CF
影响因子：
168.9
作者：
Short, Nicholas J.;Rytting, Michael E.;Cortes, Jorge E.
通讯作者：
Cortes, Jorge E.
首次完全缓解的急性髓系白血病和 17p 异常成年患者的同种异体干细胞移植：欧洲血液和骨髓移植协会 (EBMT) 急性白血病工作组 (ALWP) 的一项研究。
影响因子：
28.5
作者：
Poiré X;Labopin M;Maertens J;Yakoub-Agha I;Blaise D;Ifrah N;Socié G;Gedde-Dhal T;Schaap N;Cornelissen JJ;Vigouroux S;Sanz J;Michaux L;Esteve J;Mohty M;Nagler A
通讯作者：
Nagler A