Association between alcohol consumption in midlife and cognitive function in old age: Findings from the China health and Nutrition Survey.
Association between alcohol consumption in midlife and cognitive function in old age: Findings from the China health and Nutrition Survey.
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中年饮酒与老年认知功能的关联：中国健康与营养调查的结果。
DOI：
10.1016/j.numecd.2021.07.023
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Xu,Biao
中科院分区：
文献类型：
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作者：
Zhang,Yuge;Li,Yang;Zheng,Xubin;Zhu,Liping;Xu,Biao
背景和目的据报道，饮酒会损害老年人的身心健康。本研究旨在探讨中国中年人饮酒模式与老年人认知能力之间的关系。方法与结果研究对象为1997年中国健康与营养调查共享数据库中年龄≥45岁的个体，于2006年进行随访。使用问卷收集有关饮酒的信息（频率、数量和类型）。男性饮酒量（克/周）分为无、轻度（≤84）、轻度至中度（84.01-168）、中度至重度（168.01-336）和重度（≥336.01），女性为无、轻度（<42）和中度（≥42）。认知功能是在2006年使用认知状态修正电话访谈项目的子集来测量的。最低的五分位数被用作认知障碍的分界点。采用多元logistic回归模型。该研究涉及1926名参与者，平均年龄为56.91岁，男性占参与者总数的51.66%。饮酒行为和认知评分性别差异显著（P< 0.001）。在135名男性和237名女性中发现了认知障碍。与轻度饮酒相比，重度饮酒和不饮酒与男性认知障碍相关[校正优势比（aOR）和95% CI分别为2.19（1.59-3.00）、1.54 (1.21-1.96)；P < 0.001)。与轻度饮酒者相比，女性不饮酒者和适度饮酒者与认知障碍相关[aOR和95% CI分别为1.54（1.16-2.03）和1.75 (1.08-2.85)；P < 0.001)。结论大量饮酒对老年人认知的不良影响以及少量饮酒可能产生的保护作用的科学证据可能影响中国饮酒政策的制定。
Background and aimsAlcohol consumption has been reported to impair the physical and mental health of the elderly. This study aimed to explore the association between alcohol consumption patterns in midlife and cognition in the elderly among the Chinese population.Methods and resultsStudy subjects were individuals aged ≥45 years in the shared database of the China Health and Nutrition Survey in 1997, who were followed up in 2006. A questionnaire was used to collect information about alcohol consumption (frequency, amount and type). Alcohol consumption (grams/week) was classified into none, light (≤84), light-to-moderate (84.01–168), moderate-to-heavy (168.01–336) and heavy (≥336.01) categories in men, and none, light (<42) and moderate (≥42) categories in women. Cognitive function was measured in 2006 using a subset of items from the modified Telephone Interview for Cognitive Status. The lowest quintile was used as the cut-off point for cognitive impairment. A multivariate logistic regression model was applied. The study involved 1926 participants with a mean age of 56.91 years, and men accounted for 51.66% of the total participants. Drinking behaviours and cognitive scores had significant sexual difference (P< 0.001). Cognitive impairment was identified in 135 men and 237 women. Compared with light drinking, heavy drinking and non-drinking were associated with cognitive impairment in men [adjusted odds ratio (aOR) and 95% CI were 2.19 (1.59–3.00), 1.54 (1.21–1.96), respectively;P< 0.001]. Compared with light drinkers, female non-drinkers and moderate drinkers were associated with cognitive impairment [aOR and 95% CI were 1.54 (1.16–2.03) and 1.75 (1.08–2.85), respectively;P< 0.001].ConclusionsScientific evidence on the adverse effects of heavy drinking on elderly cognition and the possibly protective effects of light drinking could influence policy decisions on alcohol consumption in China.