Adenovirus proteins that regulate susceptibility to TNF also regulate the activity of PLA2
Adenovirus proteins that regulate susceptibility to TNF also regulate the activity of PLA2
复制标题
调节 TNF 敏感性的腺病毒蛋白也调节 PLA2 的活性
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
L. Gooding
中科院分区：
文献类型：
--
作者：
S. Laster;W. Wold;L. Gooding
摘要 腺病毒E1A蛋白的表达诱导对TNF的敏感性。为了抵消这种影响，腺病毒编码了许多基因产物，以保持宿主细胞对 TNF 的抵抗力。 E1B-19K 蛋白、E3 14.7 K 蛋白和 E3 10.4/14.5 K 二聚体各自在不同的细胞类型中发挥作用，提供对 TNF 的抵抗力。 E1A 的表达还会导致 PLA 2 的激活以及垂死细胞中花生四烯酸的释放。 E3 14.7 K 蛋白可以阻止 PLA 2 的激活，表明该蛋白除了提供宿主细胞对 TNF 的抵抗力外，还具有抗炎作用。
Abstract Expression of the adenovirus E1A protein induces susceptibility to TNF. To counteract this effect, the adenovirus encodes a number of gene products that preserve host cell resistance to TNF. The E1B-19K protein, the E3 14.7 K protein, and the E3 10.4/14.5 K dimer each function in different cell types to provide resistance to TNF. Expression of E1A also results in the activation of PLA 2 and the release of arachidonic acid from the dying cell. The E3 14.7 K protein can prevent the activation of PLA 2 , suggesting that in addition to providing host cell resistance to TNF, this protein also functions in an anti-inflammatory manner.