Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors.
Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors.
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DOI：
10.3389/falgy.2022.875295
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发表时间：
2022
影响因子：
--
通讯作者：
Silveyra, Patricia
中科院分区：
文献类型：
--
作者：
Ekpruke, Carolyn Damilola;Silveyra, Patricia
哮喘的特征是气道肌肉的收缩和炎症增加，导致气流阻塞。在青春期之前，女性哮喘的患病率低于男性，成年女性哮喘的患病率高于男性。这种在青春期开始时的性别差异和转换一直是许多研究人员争论的对象。因此，在这篇综述中，我们总结了这些观察结果，以确定需要更多研究工作的领域，并提供更好的性别特异性哮喘诊断和管理。虽然一些研究人员将其归因于男性和女性呼吸系统的解剖学和生理学差异，但青春期后激素相互作用的影响也受到了强调。其他激素如瘦素与肥胖和非肥胖患者哮喘的性别差异有关。最近，许多科学家也证明了性别特异性基因组框架作为关键角色的影响，其他人则将其与环境，社会生活方式和职业暴露联系起来。大多数研究得出的结论是，成年男性比女性更不易患哮喘，女性表现出更严重的疾病形式。因此，了解性别和性别特异性因素所起的作用，以及所涉及的生物学机制，将有助于开发新的和更准确的诊断和治疗计划，以管理性别特异性哮喘。
Asthma is characterized by an increase in the contraction and inflammation of airway muscles, resulting in airflow obstruction. The prevalence of asthma is lower in females than in males until the start of puberty, and higher in adult women than men. This sex disparity and switch at the onset of puberty has been an object of debate among many researchers. Hence, in this review, we have summarized these observations to pinpoint areas needing more research work and to provide better sex-specific diagnosis and management of asthma. While some researchers have attributed it to the anatomical and physiological differences in the male and female respiratory systems, the influences of hormonal interplay after puberty have also been stressed. Other hormones such as leptin have been linked to the sex differences in asthma in both obese and non-obese patients. Recently, many scientists have also demonstrated the influence of the sex-specific genomic framework as a key player, and others have linked it to environmental, social lifestyle, and occupational exposures. The majority of studies concluded that adult men are less susceptible to developing asthma than women and that women display more severe forms of the disease. Therefore, the understanding of the roles played by sex- and gender-specific factors, and the biological mechanisms involved will help develop novel and more accurate diagnostic and therapeutic plans for sex-specific asthma management.
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影响因子：
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作者：
Arathimos R;Suderman M;Sharp GC;Burrows K;Granell R;Tilling K;Gaunt TR;Henderson J;Ring S;Richmond RC;Relton CL
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DOI：
10.1164/rccm.200208-876oc
发表时间：
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影响因子：
24.7
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通讯作者：
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DOI：
10.1152/ajplung.00206.2019
发表时间：
2020-01-01
影响因子：
4.9
作者：
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