Copper‐Catalyzed Synthesis of 2,3‐Disubstituted Indoles
Copper‐Catalyzed Synthesis of 2,3‐Disubstituted Indoles
复制标题
DOI：
10.1002/ejoc.200700428
复制
发表时间：
2007-08
影响因子：
2.8
通讯作者：
S. Tanimori;Haruna Ura;M. Kirihata
中科院分区：
文献类型：
--
作者：
S. Tanimori;Haruna Ura;M. Kirihata
描述了从容易获得的起始原料 2-碘苯胺和各种 β-酮酯中铜催化一步合成 2,3-二取代吲哚。该方法的优点是使用廉价的催化剂、实验步骤简单、反应条件温和。由于取代的吲哚衍生物是合成具有生物活性的吲哚生物碱和候选药物的重要起始原料，因此该方法在上述目的上具有潜在的用途。（© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, German, 2007）
The copper-catalyzed one-step synthesis of 2,3-disubstituted indoles from readily available starting materials, 2-iodoaniline and various β-keto esters was described. The advantage of this method is the use of cheap catalysts and simple experimental procedures under mild reaction conditions. As the substituted indole derivatives are important starting materials for the synthesis of biologically active indole alkaloids and drug candidates, this method would have potential usage for above purpose.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)