Physical activity during daily life and mortality in patients with peripheral arterial disease
Physical activity during daily life and mortality in patients with peripheral arterial disease
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DOI：
10.1161/circulationaha.105.605246
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发表时间：
2006-07-18
期刊：
影响因子：
37.8
通讯作者：
McDermott, Mary M.
中科院分区：
文献类型：
--
作者：
Garg, Parveen K.;Tian, Lu;McDermott, Mary M.
背景-我们确定了下肢外周动脉疾病（PAD）患者谁是更多的体力活动在日常living.Methods和结果-参与者是460名男性和女性PAD（平均年龄71.9 +/- 8.4岁）随访57个月（四分位数范围36.6至61.9个月）较低的PAD患者的死亡率。在基线时，参与者被采访了他们的身体活动。垂直加速度计连续7天测量225名参与者的身体活动。分析校正了年龄、性别、种族、体重指数、高血压、吸烟、合并症、总胆固醇、HDL胆固醇、腿部症状和踝臂指数。在57个月的随访中，134名参与者（29%）死亡，其中75名参与者（33%）佩戴了加速计。通过垂直加速计测量的较高基线体力活动水平与较低的全因死亡率相关（P趋势= 0.003）。相对于加速度计测量的身体活动最高四分位数的PAD参与者，最低四分位数的PAD参与者的总死亡率较高（风险比3.48，95%置信区间1.23至9.87，P=0.019）。对于心血管事件或心血管死亡率的联合结局，观察到相似的结果（P趋势= 0.005）。1周内爬楼梯次数越多，总死亡率越低（P趋势= 0.035）。结论：日常生活中体力活动越多的PAD患者与体力活动最少的PAD患者相比，死亡率和心血管事件减少，与混杂因素无关。需要进一步的研究来确定在日常生活中增加体力活动的干预措施是否与PAD患者的生存率提高相关。
Background - We determined whether patients with lower-extremity peripheral arterial disease ( PAD) who are more physically active during daily life have lower mortality rates than PAD patients who are less active.Methods and Results - Participants were 460 men and women with PAD (mean age 71.9 +/- 8.4 years) followed up for 57 months (interquartile range 36.6 to 61.9 months). At baseline, participants were interviewed about their physical activity. Vertical accelerometers measured physical activity continuously over 7 days in 225 participants. Analyses were adjusted for age, sex, race, body mass index, hypertension, smoking, comorbidities, total cholesterol, HDL cholesterol, leg symptoms, and ankle-brachial index. At 57-month follow-up, 134 participants (29%) had died, including 75 participants (33%) who wore accelerometers. Higher baseline physical activity levels measured by vertical accelerometer were associated with lower all-cause mortality (P-trend = 0.003). Relative to PAD participants in the highest quartile of accelerometer-measured physical activity, those in the lowest quartile had higher total mortality (hazard ratio 3.48, 95% confidence interval 1.23 to 9.87, P=0.019). Similar results were observed for the combined outcome of cardiovascular events or cardiovascular mortality (P-trend = 0.005). Higher numbers of stair flights climbed during 1 week were associated with lower total mortality (P-trend = 0.035).Conclusions - PAD patients with higher physical activity during daily life have reduced mortality and cardiovascular events compared with PAD patients with the lowest physical activity, independent of confounders. Further study is needed to determine whether interventions that increase physical activity during daily life are associated with improved survival in patients with PAD.