Assessment of progression of chronic renal failure--using reciprocal of serum creatinine.
Assessment of progression of chronic renal failure--using reciprocal of serum creatinine.
复制标题
评估慢性肾衰竭的进展——使用血清肌酐的倒数。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
L. Sekaran
中科院分区：
文献类型：
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作者：
M. Muthusethupathi;S. S. Kumar;L. Sekaran
对27例慢性肾功能衰竭（CRF）患者进行了为期6至57个月的研究。平均血清肌酐（Scr.）4 mg/dl。所有患者均开始保守治疗。采用Scr倒数，通过最小二乘线性回归分析评估肾衰竭进展率。（1/Scr.）对比时间图。组I（13例患者）显示稳定进展至终末期肾衰竭（平均斜率0.013328）。13例中7例为慢性肾小球肾炎。11例有肾病蛋白尿。在组II（14例患者）中，回归线保持静止，表明肾脏疾病进展停止（平均斜率0.0087858）。14例中6例有肾硬化。3例为肾病性蛋白尿。结论：（1）1/Scr线性回归分析可作为判断CRF进展的指标。vs time是一个有用的方法。(2)持续性肾病蛋白尿是一个不利的长期危险因素。(3)保守治疗在CRF的管理中具有一定的作用。
Twenty-seven patients with chronic renal failure (CRF) were studied over a period of 6 to 57 months. The mean serum creatinine (Scr.) was 4 mg/dl. All patients were started on conservative therapy. The rate of progression of renal failure was assessed by least square linear regression analysis using reciprocal of Scr. (1/Scr.) versus time plots. Group I (13 patients) showed steady progression to end-stage renal failure (mean slope 0.013328). 7 of 13 patients had chronic glomerulonephritis. 11 had nephrotic proteinuria. In group II (14 patients), the regression line remained static indicating arrest of progression of renal disease (mean slope 0.0087858). 6 of 14 had nephrosclerosis. 3 had nephrotic proteinuria. We conclude that (1) assessment of progression of CRF by linear regression analysis of 1/Scr. vs time is a useful method. (2) persistent nephrotic proteinuria is an adverse longterm risk factor. (3) conservative therapy has a definite role in the management of CRF.