THE EMERGENCE OF ORDER IN THE DROSOPHILA PUPAL RETINA
THE EMERGENCE OF ORDER IN THE DROSOPHILA PUPAL RETINA
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DOI：
10.1016/0012-1606(89)90261-3
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发表时间：
1989-12-01
影响因子：
2.7
通讯作者：
READY, DF
中科院分区：
文献类型：
--
作者：
CAGAN, RL;READY, DF
在化蛹过程中，组成果蝇眼睛的自主发育的小眼会受到长时间的调节。为了实现这一点，出现了另外八种细胞类型：初级、次级和第三级色素细胞，以及形成刚毛的四种细胞。这些细胞在小眼之间形成交织的格子。当多余的细胞被移除时，晶格被细化，以将相邻的小眼纳入配准。最近的证据表明，在幼虫的发育过程中，局部接触直接决定细胞的命运。在发育过程中似乎也是如此：一个细胞进行的接触预测了它将成为什么类型的细胞。小眼球中与前部或后部细胞接触的细胞总是成为初级色素细胞。接触来自不同小眼的初级色素细胞的细胞成为第二级和第三级色素细胞。刚毛发育在几个方面与小眼发育不同。每个刚毛群的四个细胞似乎是单个始祖细胞的直系后代。在它们的早期分化过程中，它们不会与周围的眼球细胞进行刻板的接触，但会在刷毛群中进行特殊的接触。与周围的小眼不同，刚毛的分化是从眼睛的中心向边缘辐射的。在细胞程序性死亡的两个阶段中，当细胞被移除时，刷毛被带到它们的最终位置。当晶格中的所有细胞都达到它们的最终位置时，视网膜发育的第二阶段开始，因为产生了每种细胞类型特有的结构。这篇论文跟踪了蛹发育的这些不同阶段，并提出了局部细胞-细胞接触如何产生功能视网膜所需的细胞。
During pupation, long-range order is imposed on the autonomously developing ommatidia which compose the Drosophila eye. To accomplish this, eight additional cell types arise: the primary, secondary, and tertiary pigment cells, and the four cells that form the bristle. These cells form an interweaving lattice between ommatidia. The lattice is refined when excess cells are removed to bring neighboring ommatidia into register. Recent evidence suggests that in larval development, local contacts direct cell fate. The same appears to be true during development: the contacts a cell makes predict the cell type it will become. Cells which contact the anterior or posterior ones cells in an ommatidium invariably become primary pigment cells. Cells which contact primary pigment cells from different ommatidia become secondary and tertiary pigment cells. Bristle development is in several ways distinct from ommatidial development. The four cells of each bristle group appear to be immediate descendents of a single founder cell. During their early differentiation, they do not make stereotyped contacts with surrounding ommatidial cells, but do make particular contacts within the bristle group. And unlike the surrounding ommatidia, differentiation of the bristles radiates from the center of the eye to the edges. As cells are removed during two stages of programmed cell death, the bristles are brought into their final position. When all cells in the lattice have achieved their final position, a second stage of retinal development begins as structures specific to each cell type are produced. This paper follows these various stages of pupal development, and suggest how local cell-cell contacts may produce the cells needed for a functional retina.