A possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection
A possible treatment strategy and clinical factors to estimate the treatment response in Bebesia gibsoni infection
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DOI：
10.1292/jvms.69.563
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发表时间：
2007-05-01
影响因子：
1.2
通讯作者：
Endo, Yasuyuki
中科院分区：
文献类型：
--
作者：
Suzuki, Koretoki;Wakabayashi, Haruna;Endo, Yasuyuki
联合治疗使用克林霉素，甲硝唑和多西环素对犬巴贝虫病的有效性，血小板计数和血浆C-反应蛋白（CRP）浓度作为治疗的估计因素的有用性，进行了评估，在四只狗实验感染吉氏巴贝虫。联合治疗成功消除了B。4只狗中的3只在外周血中检测到Gibsoni，然而，剩余的狗在暂时恢复后显示出明显的不受控制的复发。此外，研究表明，CRP水平降低与红细胞压积恢复成反比，因此CRP水平可用作估计治疗应答的可选临床标志物。
The effectiveness of combination therapy using clindamycin, metronidazole and doxycycline against canine babesiosis, and the usefulness of platelet count and the plasma C-reactive protein (CRP) concentration as an estimation factor for treatment, were evaluated in four dogs experimentally infected with Babesia gibsoni. The combination therapy successfully eliminated B. gibsoni in peripheral blood in 3 of 4 dogs, however the remaining dog showed obvious uncontrolled relapse after a temporary recovery. In addition, it was shown that CRP levels decreased in an inverse relationship to the recovery of packed cell volume and therefore CRP levels could be used as an optional clinical marker to estimate the response to treatment.