Maintenance of endothelial function following acute resistance exercise in females is associated with a tempered blood pressure response
Maintenance of endothelial function following acute resistance exercise in females is associated with a tempered blood pressure response
复制标题
DOI：
10.1152/japplphysiol.00378.2020
复制
发表时间：
2020-10-01
影响因子：
3.3
通讯作者：
Ochi, Eisuke
中科院分区：
文献类型：
--
作者：
Morishima, Takuma;Padilla, Jaume;Ochi, Eisuke
急性阻力运动诱发的高血压刺激损害男性内皮功能。由于先前的工作表明，女性受试者有一个温和的血压反应，急性阻力运动，我们假设，与男性相比，女性将更好地维持内皮功能阻力运动后，这种保存将与低血压刺激。29名年轻健康男性（n = 16）和女性（n = 13）参加了本研究。所有受试者在相同的相对工作量[一次重复最大值的65%（1RM）]下进行一次抗阻运动（腿部伸展）。观察运动对血压的影响，并测量运动前后肱动脉血流介导的舒张功能（FMD）。男性进行了第二次实验，其中血压对阻力运动的反应与女性相匹配。这是通过减少工作量（相当于1RM的25%）来实现的。在相同相对负荷下进行抗阻运动时，男性收缩压高于女性。抗阻运动对男性FMD有显著影响，但对女性无显著影响（P < 0.001）。当运动负荷减少时，男性在抗阻运动后FMD不再表现出损害，因此，性别差异消失（P > 0.05）。本研究表明，急性抗阻运动短暂损害内皮功能的年轻，健康的男性，但在年龄匹配的女性。值得注意的是，在女性的内皮功能的维护与阻力exercise.NEW &值得注意的是，本数据首次表明，急性阻力运动损害内皮功能的年轻，健康的男性，但不是女性受试者的血压反应较低。此外，我们发现，女性内皮功能的保护与抗阻运动期间血压反应的减轻有关。因此，这项工作描绘了性的二型性的压力反应，并随之而来的血管效应，阻力运动。
Acute resistance exercise-induced hypertensive stimulus impairs endothelial function in males. Because prior work indicates that female subjects have a tempered blood pressure response to acute resistance exercise, we hypothesized that, compared with males, females would better maintain endothelial function following resistance exercise and that this preservation would be associated with a lower hypertensive stimulus. Twenty-nine young healthy males (n = 16) and females (n = 13) participated in this study. All subjects performed a session of resistance exercise (leg extension) at the same relative workload [65% of one repetition maximum (1RM)]. The blood pressure response to exercise was characterized, and brachial artery flow-mediated dilation (FMD) was measured before and after. Males performed a second experimental trial in which the blood pressure response to resistance exercise was matched to that of females. This was accomplished by reducing the workload (similar to 25% of 1RM). When resistance exercise was performed at the same relative workload, the systolic blood pressure was greater in males compared with females. Congruently, resistance exercise caused a significant impairment in FMD in males but not in females (P < 0.001). When the exercise workload was reduced in males, they no longer displayed an impairment in FMD following resistance exercise and, as such, the sex difference was abolished (P > 0.05). The present study reveals that acute resistance exercise transiently impairs endothelial function in young, healthy males but not in age-matched females. Notably, the maintenance of endothelial function in females is associated with a lower blood pressure response during resistance exercise.NEW & NOTEWORTHY The present data demonstrate for the first time that acute resistance exercise impairs endothelial function in young, healthy male but not female subjects. In addition, we show that the preservation of endothelial function in females is associated with a mitigated blood pressure response during resistance exercise. Accordingly, this work portrays a sexual dimorphism in the barostress response, and ensuing vascular effects, to resistance exercise.