Membrane Transport at an Organelle Interface in the Early Secretory Pathway: Take Your Coat Off and Stay a While: Evolution of the metazoan early secretory pathway.
Membrane Transport at an Organelle Interface in the Early Secretory Pathway: Take Your Coat Off and Stay a While: Evolution of the metazoan early secretory pathway.
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DOI：
10.1002/bies.201800004
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Audhya A
中科院分区：
文献类型：
--
作者：
Hanna MG;Peotter JL;Frankel EB;Audhya A
大多数后生动物在早期分泌途径中进化出一个轻度酸化和钙减少的分选中心，通常称为内质网-高尔基体中间室（ERGIC）。这些膜囊泡管状簇被发现紧密并列的ER亚域，是生产COPII包被的运输载体的主管。与许多单细胞系统相反，后生动物COPII载体在COPI依赖运输到顺式高尔基体之前，大部分转运到ERGIC只有几百纳米。ERGIC膜的形成和维持机制还不清楚。然而，最近的证据表明，Trk融合基因（TFG）在调节ER/ERGIC界面的完整性中起重要作用。此外，在没有细胞骨架元件的情况下，支架轨道上的COPII载体可能会移动，TFG似乎促进顺行货物运输的局部拴系COPII载体附近的ERGIC膜。该作用部分地由TFG的固有无序结构域调节，在异型膜融合和货物递送至ERGIC之前为COPII外壳解体提供足够的时间。
Most metazoan organisms have evolved a mildly acidified and calcium diminished sorting hub in the early secretory pathway commonly referred to as the Endoplasmic Reticulum-Golgi intermediate compartment (ERGIC). These membranous vesicular-tubular clusters are found tightly juxtaposed to ER subdomains that are competent for the production of COPII-coated transport carriers. In contrast to many unicellular systems, metazoan COPII carriers largely transit just a few hundred nanometers to the ERGIC, prior to COPI-dependent transport on to the cis-Golgi. The mechanisms underlying formation and maintenance of ERGIC membranes are poorly defined. However, recent evidence suggests an important role for Trk-fused gene (TFG) in regulating the integrity of the ER/ERGIC interface. Moreover, in the absence of cytoskeletal elements to scaffold tracks on which COPII carriers might move, TFG appears to promote anterograde cargo transport by locally tethering COPII carriers adjacent to ERGIC membranes. This action, regulated in part by the intrinsically disordered domain of TFG, provides sufficient time for COPII coat disassembly prior to heterotypic membrane fusion and cargo delivery to the ERGIC.
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