Soft tissue sarcoma after treatment for breast cancer - A Swedish population-based study
Soft tissue sarcoma after treatment for breast cancer - A Swedish population-based study
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DOI：
10.1016/s0959-8049(98)00319-0
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发表时间：
1998-12-01
影响因子：
8.4
通讯作者：
Wallgren, A
中科院分区：
文献类型：
--
作者：
Karlsson, P;Holmberg, E;Wallgren, A
目的是量化乳腺癌患者治疗后发生肉瘤的风险，对1958年至1992年瑞典癌症登记处所有122991例乳腺癌妇女进行了软组织肉瘤随访，发现116例，标准化发病率为1.9（95%CI 1.5-2.2）。绝对风险为13/10（4）人年。肿瘤位于乳腺或同侧上肢者占63%（67/106），其中血管瘤40例，其他类型76例。在一项病例对照研究中，血管肉瘤与手臂淋巴水肿显著相关，比值比（OR）9.5（95%CI 3.2-28.0），但未观察到与放疗相关。对于其他类型的肉瘤，积分剂量有相关性。剂量-反应关系表明，在150- 200 J的积分剂量下，风险线性增加，并在较高能量下稳定。50 J能量的OR为2.4（95% CI 1.4-4.2），大致相当于保乳手术后的乳房辐射。因此，只有手臂水肿与血管肉瘤相关，但对于其他类型的肉瘤，放疗的积分剂量是风险的预测因子。(C)1998爱思唯尔科技有限公司版权所有。
The aim was to quantify the risk of post-treatment sarcoma in breast cancer patients, All 122991 women with a breast cancer from 1958 to 1992 in the Swedish Cancer Register were followed up for soft tissue sarcomas and 116 were found, giving a standardised incidence ratio of 1.9 (95% CI 1.5-2.2). The absolute risk was 13 per 10(4) person-years. The sarcomas were located in the breast region or on the ipsilateral arm in 63% (67/106), There were 40 angiosarcomas and 76 sarcomas of other types. In a case-control study, angiosarcoma correlated significantly with lymphoedema of the arm, odds ratio (OR) 9.5 (95% CI 3.2-28.0), but no correlation with radiotherapy was observed. For other types of sarcoma there was a correlation with the integral dose. The dose-response relationship indicated that the risk increased linearly with the integral dose to 150-200J and stabilised at higher energies. The OR was 2.4 (95% CI 1.4-4.2) for an energy of 50J, approximately corresponding to the radiation of the breast after breast-conserving surgery. Thus, only oedema of the arm correlated with angiosarcoma, but for other types of sarcoma the integral dose of radiotherapy was a predictor of the risk. (C) 1998 Elsevier Science Ltd. All rights reserved.