Addressing chromosome evolution in the whole-genome sequence era
Addressing chromosome evolution in the whole-genome sequence era
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DOI：
10.1007/s10577-007-1208-0
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发表时间：
2008-03-01
影响因子：
2.6
通讯作者：
Faraut, Thomas
中科院分区：
文献类型：
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作者：
Faraut, Thomas
自20世纪中期以来，核型的进化一直是深入研究的主题。这是由于观察到相关物种的核型表现出显著的保守性。最近出现的全基因组测序项目提供了机会，以补充细胞遗传学的方法，通过解决核型的保存使用染色体序列比较。在这篇简短的综述中，我们介绍了用于研究染色体进化和更具体的祖先核型重建的计算生物学方法的最新进展，试图提供细胞遗传学和计算方法的综合概述。
The evolution of karyotypes has been the subject of intensive study since the middle of the 20th century. This was motivated by the observation that the karyotypes of related species showed remarkable conservation. The recent emergence of whole-genome sequencing projects gives the opportunity to complement the cytogenetic approaches by addressing the conservation of karyotypes using chromosome sequence comparison. In this short review we present a description of recent advances in computational biology methods dedicated to the study of chromosome evolution and more specifically ancestral karyotype reconstruction in an attempt to provide an integrated overview of both cytogenetic and computational approaches.