THE HIPPOCAMPUS IN EXPERIMENTAL CHRONIC EPILEPSY - A MORPHOMETRIC ANALYSIS
THE HIPPOCAMPUS IN EXPERIMENTAL CHRONIC EPILEPSY - A MORPHOMETRIC ANALYSIS
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DOI：
10.1002/ana.410270108
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发表时间：
1990-01-01
影响因子：
11.2
通讯作者：
LENN, NJ
中科院分区：
文献类型：
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作者：
BERTRAM, EH;LOTHMAN, EW;LENN, NJ
间歇性癫痫发作对海马锥体神经元的影响在很大程度上是未知的。为了确定以海马为中心的复发性癫痫发作是否会在该区域产生神经元损失，使用5组动物从海马的标准化切片进行形态测定分析：（1）手术对照受试者，（2）通过快速复发性海马癫痫发作（RRHS）范例点燃的大鼠，（3）具有少量额外边缘系统癫痫发作的点燃大鼠（528 ± 0.5%）。66次癫痫发作），（4）多次边缘癫痫发作的点燃大鼠（1，523. ±. 130次癫痫发作），和（5）经历由“连续”海马刺激诱导的边缘系统癫痫持续状态（SE）的大鼠。RRHS和SE方案诱导CA1区显著的神经元损失，但没有证据表明随着间歇性癫痫发作次数的增加会出现额外的细胞损失。然而，这些间歇性癫痫发作与CA1区的基底和顶端树突区显著增厚相关。这些结果表明，间歇性癫痫发作不产生显着的海马神经元的损失，并可能导致肥大的CA 1树突领域。
The effect of intermittent seizures on the pyramidal neurons of the hippocampus is largely unknown. To determine whether recurrent seizures centered in the hippocampus can produce neuronal loss in this region, a morphometric analysis was performed from standardized sections of hippocampus using 5 groups of animals: (1) surgical control subjects, (2) rats kindled by the rapidly recurring hippocampal seizure (RRHS) paradigm, (3) kindled rats with a few additional limbic seizures (528 .+-. 66 seizures), (4) kindled rats with many limbic seizures (1,523 .+-. 130 seizures), and (5) rats experiencing limbic status epilepticus (SE) induced by "continuous" hippocampal stimulation. The RRHS and SE protocols induced significant neuronal loss in the CA1 region, but no evidence was found for additional cell loss with increasing numbers of intermittent seizures. These intermittent seizures were, however, associated with a significant thickening of the basal and apical dendritic fields of the CA1 region. These findings indicate that intermittent seizures produce no significant hippocampal neuronal loss and may result in a hypertrophy of CA1 dendritic fields.