Effects of copper-based dental casting alloys on two lymphocyte cell lines and the secretion of interleukin 2 and IgG.
Effects of copper-based dental casting alloys on two lymphocyte cell lines and the secretion of interleukin 2 and IgG.
复制标题
铜基牙科铸造合金对两种淋巴细胞系以及白细胞介素2和IgG分泌的影响。
DOI：
10.1016/0109-5641(93)90080-a
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Tilden,AB
中科院分区：
文献类型：
--
作者：
Bumgardner,JD;Lucas,LC;AlversonJr,MW;Tilden,AB
在口腔环境中，牙龈淋巴细胞参与维持牙周组织的局部免疫防御。铜基牙科铸造合金的腐蚀速率和宿主牙龈中腐蚀产物的积累引起了人们对这些腐蚀产物对口腔免疫反应影响的担忧。本研究的目的是调查铜牙科合金腐蚀产物可能改变免疫功能的假设。体外细胞培养研究用于分析三种铜基牙科合金分别对 T 细胞和 B 细胞系及其可溶性免疫介质 (IL-2) 和效应物 (lgG) 分泌的影响。这项研究的结果表明，铜合金在 24 小时内释放的腐蚀产物能够降低细胞活力、改变增殖并调节可溶性免疫介质的产生。这些结果支持这样的假设：铜牙科合金腐蚀产物可能会改变免疫反应，从而导致多种牙科病理状况。
In the oral environment, gingival lymphocytes are involved in maintaining the local immune defense of periodontal tissues. The corrosion rates of copper-based dental casting alloys and the accumulation of corrosion products in host gingiva raise concerns about the effects of these corrosion products on immune responses in the oral cavity. The aim of this study was to investigate the hypothesis that immune function may be altered by copper dental alloy corrosion products.In vitrocell culture studies were used to analyze the effects of three copper-based dental alloys on a T-cell and B-cell line and their secretion of soluble immune mediators (IL-2) and effectors (lgG), respectively. Results of this study revealed that corrosion products released from copper alloys in 24 h have the ability to reduce cellular viability, alter proliferation, and modulate the production of soluble immune mediators. These results support the hypothesis that copper dental alloy corrosion products may alter immune responses and thereby contribute to a variety of dental pathological conditions.