A NOVEL BIOLOGICALLY-ACTIVE ORGANOSELENIUM COMPOUND .1. GLUTATHIONE PEROXIDASE-LIKE ACTIVITY INVITRO AND ANTIOXIDANT CAPACITY OF PZ-51 (EBSELEN)
A NOVEL BIOLOGICALLY-ACTIVE ORGANOSELENIUM COMPOUND .1. GLUTATHIONE PEROXIDASE-LIKE ACTIVITY INVITRO AND ANTIOXIDANT CAPACITY OF PZ-51 (EBSELEN)
复制标题
DOI：
10.1016/0006-2952(84)90083-2
复制
发表时间：
1984-01-01
影响因子：
5.8
通讯作者：
SIES, H
中科院分区：
文献类型：
--
作者：
MULLER, A;CADENAS, E;SIES, H
A synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activityin vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.
