ARCHITECTURE OF APICAL DENDRITES IN THE MURINE NEOCORTEX - DUAL APICAL DENDRITIC SYSTEMS
ARCHITECTURE OF APICAL DENDRITES IN THE MURINE NEOCORTEX - DUAL APICAL DENDRITIC SYSTEMS
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DOI：
10.1016/0306-4522(86)90074-6
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发表时间：
1986-04-01
期刊：
影响因子：
3.3
通讯作者：
KOSIK, KS
中科院分区：
文献类型：
--
作者：
ESCOBAR, MI;PIMIENTA, H;KOSIK, KS
抗微管相关蛋白2的单克隆抗体（5 F9）是小鼠新皮质树突的选择性和敏感性标记物。标记物染色所有树突。它提供了一个特别全面的图片的顶端树突的安排，这是最强烈的染色与这种抗体的模式。顶端树突的双重系统一方面来自第VI层的多态神经元，另一方面来自第II-V层的锥体神经元。前者的末端树枝化主要集中在第V层和第IV层的界面处，而后者则集中在分子层中。两个系统的顶端树突被分组为束。在颗粒上层和上层VI-下层V，其中顶端树突最丰富，束合并成隔膜。这些产生蜂窝状图案，将这些皮层水平细分成直径约20-40 μ m的柱状空间。在第四层的水平，其中顶端树突的数量大大减少，束是孤立的束。这些束分别在初级躯体感觉区、颞区和额叶区具有圆形、椭圆形或矩形柱的形式。在筒场中的那些优先集中在筒的侧面和筒间隔膜。树突束，特别是中皮质束的构型可能符合中间神经元的投射轴突的空间构型。
A monoclonal antibody (5F9) against microtubule-associated protein 2 is a selective and sensitive marker for neocortical dendrites in the mouse. The marker stains all dendrites. It affords a particularly comprehensive picture of the patterns of arrangements of apical dendrites which are most intensely stained with this antibody. Dual systems of apical dendrites arise from the polymorphic neurons of layer VI, on the one hand, and the pyramidal neurons of layers II-V, on the other. Terminal arborization of the former is concentrated principally at the interface of layers V and IV, while that of the latter is in the molecular layer. Apical dendrites of both systems are grouped into fascicles. In supragranular layers and in upper layer VI-lower layer V, where apical dendrites are most abundant, the fascicles coalesce into septa. These generate a honeycomb-like pattern, subdividing these cortical levels into columnar spaces of approximately 20-40 .mu.m diameter. At the level of layer IV, where the number of apical dendrites is greatly reduced, the fascicles are isolated bundles. These bundles have the form of circular, elliptical or rectangular columns in the primary somatosensory, temporal and frontal regions, respectively. Those in the barrel field are preferentially concentrated in the sides of barrels and the interbarrel septa. The configurations of the dendritic fascicles, particularly the midcortical bundles, may conform to the spatial configuration of investing axons of interneurons.